在疫苗诱导的免疫性血栓性血栓性缺血症之后,对SARS-CoV-2的后续接种疫苗
Günalp Uzun1,2, Theresa Ringelmann2, Stefanie Hammer1,2
1Centre for Clinical Transfusion Medicine Tuebingen, 72076 Tuebingen, Germany.
Journal of clinical medicine
|September 28, 2024
概括
以后用mRNA疫苗接种COVID-19疫苗对于以前经历过疫苗诱导的免疫血栓性血栓性缺血症 (VITT) 的患者是安全的. 这些患者在接种mRNA疫苗后没有出现新的血栓栓塞事件或显著的血小板下降.
科学领域:
- 免疫学 免疫学 免疫学
- 血液学 血液学 血液学
- 疫苗学 疫苗学 疫苗学
背景情况:
- 疫苗诱发的免疫血栓性血栓性缺血症 (VITT) 是一种罕见但严重的不良事件,与腺病毒载体COVID-19疫苗有关.
- 抗血小板因子4 (PF4) 的抗体与VITT的发病有关,导致血小板激活和血栓形成.
- 由于潜在的再血栓形成,对VITT患者随后接种COVID-19疫苗的安全性存在担忧.
研究的目的:
- 在被诊断患有VITT的患者中评估后续COVID-19疫苗接种的安全性和结果.
- 评估VITT幸存者的疫苗接种后的新血栓栓塞事件和血小板计数的变化.
主要方法:
- 接下来接种COVID-19mRNA疫苗的四名VITT患者的潜在随访.
- 血小板计数,抗PF4/肝素抗体水平和功能血小板检测的监测.
- 在VITT患者中报告的后续接种疫苗的文献综述.
主要成果:
- 四名VITT患者最初接种了ChAdOx1 nCoV-19,随后接种了mRNA疫苗,没有任何不良事件.
- 抗PF4/肝素抗体水平通常随着时间的推移而下降,三名患者在4个月内检测出阴性.
- 在研究患者的随访期间或对七例类似病例的文献综述中,没有观察到显著的血小板缩或新的血栓栓塞并发症.
结论:
- 随后用mRNA疫苗接种疫苗似乎对有VITT病史的人来说是安全的.
- 在VITT患者中,mRNA疫苗可能是完成COVID-19免疫接种的合适选择.
- 进一步的研究可以证实mRNA疫苗接种在这种特定患者队列中的长期安全性和有效性.
更多相关视频
06:03Author Spotlight: Advancing Immune Monitoring in Critical Care Patients Using Whole Blood Assays
Published on: September 20, 2024
1.2K
08:10Simultaneous Quantification of Anti-vector and Anti-transgene-Specific CD8+ T Cells Via MHC I Tetramer Staining After Vaccination with a Viral Vector
Published on: November 28, 2018
8.5K
相关概念视频
01:51Vaccinations
44.1K
Overview
44.1K
01:23Immunological Memory
554
Immunological memory, a pivotal pillar of the adaptive immune system, is responsible for the body's ability to remember and respond more swiftly and effectively to previously encountered pathogens. This remarkable feature is what makes vaccines so effective in preventing diseases.
What is Immunological Memory?
Immunological memory is an integral function of the immune system that allows it to recognize and react more rapidly and effectively to pathogens previously encountered. This feature...
What is Immunological Memory?
Immunological memory is an integral function of the immune system that allows it to recognize and react more rapidly and effectively to pathogens previously encountered. This feature...
554
01:29Venous Thrombosis III: Interprofessional Care
3
Venous thrombosis requires effective prevention and treatment strategies to improve patient outcomes and reduce potential complications.Prevention StrategiesHealthcare providers must prioritize preventing venous thromboembolism (VTE) for all adult patients upon admission. Interventions depend on bleeding and thrombosis risk, medical history, current medications, diagnoses, planned procedures, and patient preferences. Patients on bed rest should change positions every two hours and, if not...
3
01:14Myocarditis III: Medical Management
2
Myocarditis: Comprehensive Medical ManagementMyocarditis, the heart muscle inflammation, requires a comprehensive medical management strategy that addresses the underlying cause, provides supportive care, manages symptoms, and reduces cardiac workload.Infections and Autoimmune CausesAdminister appropriate antimicrobial therapy when an infectious agent causes myocarditis. For instance, penicillin treats infections caused by Group A Streptococcus. In cases where autoimmune processes are...
2
00:42Cross-reactivity
31.0K
Overview
31.0K