心脏衰竭中的心脏上脂肪与保存的喷射分数相比,减少的喷射分数相比
Gurwinder S Sidhu1, Simon W Rabkin1,2
1Faculty of Medicine, University of British Columbia, Vancouver, BC V6T 1Z3, Canada.
Journal of clinical medicine
|September 28, 2024
概括
在心脏衰竭中,心脏脂肪显著增加,心脏衰竭的喷射分数保留 (HFpEF) 与心脏衰竭的喷射分数减少 (HFrEF) 相比. 心上脂肪增加与HFpEF中较小的心室有关.
科学领域:
- 心脏病学 心脏病学
- 医疗成像医学成像
- 生物医学科学 生物医学科学
背景情况:
- 心上脂肪组织 (EAT) 在心力衰竭中具有保存的喷射分数 (HFpEF) 的特定作用需要进一步阐明.
- 了解EAT的贡献对于开发针对HFpEF的向疗法至关重要.
研究的目的:
- 研究心表脂肪组织 (EAT) 与HFpEF患者的心脏结构和功能之间的关系.
- 为了比较HFpEF和心力衰竭之间的EAT测量,减少喷射率 (HFrEF) 患者.
主要方法:
- 在诊断为患有慢性心力衰竭 (HFpEF,HFrEF,或透心功能障碍) 的门诊患者中,对心脏表皮脂肪厚度的心声图评估.
- 对EAT测量与各种心脏结构和功能指数的相关性分析,包括腔室尺寸和体积.
- 对体重指数 (BMI) 和年龄进行统计调整,以精确观察到的关联.
主要成果:
- 与HFrEF患者 (5.1 ± 1.0毫米) 相比,HFpEF患者 (6.7 ± 1.6毫米) 的心上脂肪厚度显著增加.
- 在HFpEF中,增加的EAT与左心室内部直径 (LVIDd,LVIDs),LV末端透气体积指数和心房/右心房体积指数显著负相关.
- 这些关联,除了血红蛋白,在调整BMI后仍然显著.
结论:
- 在HFpEF患者中,心上脂肪的含量明显高于HFrEF患者.
- HFpEF上升的上心脂肪与心室尺寸较小有关,这表明它可能会阻碍心脏扩张.
相关概念视频
01:17Pathophysiology of Heart Failure
1.5K
Heart failure (HF) is a progressive syndrome involving ventricles that leads to inadequate cardiac output. It can be classified based on location and output or ejection fraction. Ejection fraction (EF) is an essential measurement in the diagnosis and surveillance of HF. Reduced EF corresponds to systolic heart failure (HFrEF). However, HF with preserved ejection fraction (HFpEF) is becoming increasingly prevalent. Also known as diastolic HF, this form of HF is related to aging. The...
1.5K
01:29Heart Failure II: Pathophysiology
3
Systolic Heart Failure and Compensatory MechanismsSystolic heart failure (also termed HFrEF, Heart Failure with Reduced Ejection Fraction) is the most prevalent type of heart filure. It results in a decreased volume of blood being pumped from the ventricle. The aortic arch and carotid sinuses have baroreceptors that detect reduced blood pressure, triggering the sympathetic nervous system (SNS) to release epinephrine and norepinephrine. Initially, this response aims to boost heart rate and...
3
01:30Heart Failure IV: Classification and Diagnostic Evaluation
2
Heart failure can be classified in various ways, with the most common classifications based on physical activity limitations, disease progression, severity, and treatment strategies.The Functional Classification of Heart Failure divides patients into four categories based on physical activity limitation due to symptom burden.Class I: Patients in this class have cardiac disease but no physical activity limitations. Ordinary activities like walking, climbing stairs, or routine tasks do not cause...
2
01:26Heart Failure III: Clinical Manifestations
3
Heart failure (HF) manifests primarily as dyspnea, fatigue, and fluid retention, resulting in peripheral and pulmonary edema. Symptoms may vary depending on which ventricle is more affected, left or right.Left-Sided Heart FailureAlso known as left ventricular failure, this condition results from the left ventricle's inability to fill or eject sufficient blood into the systemic circulation. It leads to pulmonary congestion, which occurs when the left ventricle fails to eject blood effectively...
3
01:27Heart Failure I: Introduction
2
Heart failure refers to a clinical syndrome caused by structural or functional cardiac disorders that prevent the heart from pumping an adequate amount of blood to meet the body's metabolic needs. This condition often arises from myocardial infarction or ischemia, leading to decreased cardiac output, reduced tissue perfusion, impaired gas exchange, fluid volume imbalance, and decreased functional ability.Heart failure can result from disruptions in the mechanisms that regulate cardiac output...
2
01:26Imbalances in Cardiac Output
1.4K
The heart's primary function is to pump blood throughout the body, maintaining a balance between blood sent out (cardiac output) and blood returning (venous return). If this balance is disrupted, it can result in congestive heart failure (CHF), a severe condition where the heart becomes an inefficient pump, leading to inadequate blood circulation.
CHF can occur due to the failure of either side of the heart. Left-side failure leads to pulmonary congestion—the right side continues to send...
CHF can occur due to the failure of either side of the heart. Left-side failure leads to pulmonary congestion—the right side continues to send...
1.4K