心房动与认知功能障碍的关联:对当前理解和最近的更新进行了全面的叙述性审查
Siddhant Passey1, Jay Patel1, Haris Patail2
1Department of Internal Medicine, University of Connecticut School of Medicine, Farmington, CT 06030, USA.
Journal of clinical medicine
|September 28, 2024
概括
心房动 (AF) 与认知衰退和痴呆症有关,即使考虑到其他健康问题. 抗凝剂和导管切除等治疗可以帮助管理这种关联.
科学领域:
- 心脏病学 心脏病学
- 神经学 神经学
- 老年病的医生 老年病的医生
背景情况:
- 心房动 (AF) 是成年人中最常见的心律失常.
- 在全球范围内,AF和痴呆症的患病率都在增加.
- 有证据表明,AF与认知功能障碍 (包括痴呆症) 之间存在联系.
研究的目的:
- 审查AF-痴呆症协会的流行病学,病理生理学,神经成像,治疗影响和社会经济后果.
- 综合目前关于AF和认知障碍之间的关系的证据.
主要方法:
- 观察性研究和元分析的审查.
- 讨论拟议的病理生理机制.
- 分析神经成像,治疗方法和临床结果.
主要成果:
- AF与认知能力下降有关,独立于中风史和共同的风险因素 (高血压,糖尿病).
- 建议的机制包括静音心脏病发作,微型血流,低 perfusion,炎症和动脉样硬化.
- 抗凝剂可能会减缓认知能力的下降;导管切除显示了尽管短期的缺陷,长期的认知效益.
结论:
- 在AF和认知衰退之间的关联是成熟的,有多种因素.
- 需要进一步研究神经成像在治疗决策中的作用以及社会决定因素对结果的影响.
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