在慢性乙型肝炎和代谢功能障碍相关的肝病同时出现的独特临床和病毒学特征:基于人口的队列研究的见解
Fadi Abu Baker1, Abdel-Rauf Zeina1,2, Randa Taher1
1Department of Gastroenterology and Hepatology, Hillel Yaffe Medical Center, Technion Faculty of Medicine, Hadera 38100, Israel.
Journal of clinical medicine
|September 28, 2024
概括
患有慢性乙型肝炎 (CHB) 和代谢功能障碍相关的脂肪性肝病 (MASLD) 的患者表现出明显的特征,包括年龄较大,肥胖和糖尿病的发病率较高. 这种共感染可能与疾病进展和结果的恶化有关.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 病毒学 病毒学
- 代谢性疾病 代谢性疾病
背景情况:
- 同时的慢性乙型肝炎病毒 (CHB) 感染和与代谢功能障碍相关的脂肪性肝病 (MASLD) 构成了复杂的临床挑战.
- 了解CHB和MASLD之间的相互作用对于管理肝病进展和患者结果至关重要.
研究的目的:
- 描述MASLD患者中CHB的独特临床和病毒学特征.
- 评估MASLD对CHB进展和结果的影响.
主要方法:
- 一项回顾性研究分析了2000-2020年间的1186名CHB患者,将他们分为CHB-MASLD (n=188) 和单独的CHB (n=998) 组.
- 通过血清学标记证实了CHB,并使用成像和心脏代谢风险因素诊断了MASLD.
- 对比分析和多变量回归模型评估了病毒参数和临床结果.
主要成果:
- 而CHB-MASLD组的年龄较大,肥胖,糖尿病和脂质失调的发病率较高.
- 在CHB-MASLD中,不同的病毒形状包括更高的HBeAg阴性和更高的HBeAg血清转化率.
- 肝硬化患病率在CHB-MASLD组中较高,而肝细胞癌 (HCC) 的发生率相似.
结论:
- 在CHB-MASLD患者中,存在显著的代谢并发病症和独特的病毒形状.
- 这些发现表明,CHB-MASLD与不良肝病结果之间存在潜在的关联.
- 年龄,男性性别,慢性活性肝炎和糖尿病被确定为这种队列中肝硬化的预测因素.
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