大麻使用变化和心肌梗塞:系统性审查
Jan van Amsterdam1,2, Wim van den Brink1,2
1Department of Psychiatry, Amsterdam UMC, University of Amsterdam, Meibergdreef 9, P.O. Box 22660, 1100 DD Amsterdam, The Netherlands.
Journal of clinical medicine
|September 28, 2024
概括
吸食大麻,与vaping或食用食品不同,独立增加心肌梗塞 (MI) 风险,即使在非烟草使用者. 这突显了燃烧是大麻相关心血管事件的关键因素.
科学领域:
- 心血管疾病流行病学
- 大麻与公共卫生
- 吸入烟雾的毒理学
背景情况:
- 大麻使用与冠心病 (CHD) 的增加有关,包括心肌梗塞 (MI) 和胸痛 (AP).
- 由于经常与烟草共同使用,大麻使用对心脏病发作的独立风险尚不清楚.
- 调查与不同大麻消费方法 (吸烟,蒸汽,食用品) 相关的特定风险至关重要.
研究的目的:
- 确定大麻是否是心肌梗塞 (MI) 的独立风险因素.
- 为了比较不同大麻消费方法中心血管中风的风险:吸烟,蒸汽和食用食品.
- 评估同时使用烟草对与大麻有关的心脏病发作风险的影响.
主要方法:
- 按照PRISMA指南进行的系统审查.
- 在Medline (PubMed),Embase和谷歌学者数据库中进行的搜索.
- 对22项符合条件的研究进行分析,以评估大麻使用与心脏病发作之间的关联.
主要成果:
- 吸食大麻显示与心脏病发作有显著的关联 (aORs 1.035.24),即使在调整烟草使用后.
- 经常吸食大麻会造成显著的脑筋梗塞风险 (aOR=1.88),即使在从未吸烟的人群中也是如此.
- 大麻的蒸汽和摄入 (非吸烟形式) 与心血管风险增加没有显著关联 (频繁使用:aOR = 1.00 ns;当前使用:aOR = 1.31 ns).
结论:
- 吸食大麻可能会独立引发心肌梗塞 (MI),类似于吸烟.
- 非可燃大麻消费方法,如蒸汽和摄入似乎不那么有害.
- 减少蒸汽/摄入的危害可能源于避免大麻烟雾中存在的毒素,如一氧化碳.
关键词:
大麻大麻大麻大麻大麻大麻大麻大麻一氧化碳的一氧化碳.冠心病是一种冠心病.可食用食品 可食用食品.大麻大麻大麻大麻是什么意思心肌梗塞的心脏病发作吸烟是为了吸烟.电子烟 (vaping) 是一种电子烟.更多相关视频
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