产前压力和乙醇暴露:微生物群诱导的免疫失调和精神病风险
Rosana Camarini1, Priscila Marianno1, Maylin Hanampa-Maquera1
1Department of Pharmacology, Institute of Biomedical Sciences, Universidade de São Paulo, São Paulo 05508-900, Brazil.
International journal of molecular sciences
|September 28, 2024
概括
母亲的压力和乙醇暴露会破坏肠道微生物群,影响后代的免疫力,增加抑郁症的风险. 针对肠-大脑轴的干预措施对于母亲和儿童的心理健康至关重要.
科学领域:
- 神经科学是一个神经科学.
- 微生物学 微生物学
- 免疫学 免疫学 免疫学
背景情况:
- 母体肠道微生物群在后代的发育中起着至关重要的作用.
- 压力和乙醇暴露可以诱导孕产妇的肠道失调.
- 肠道失调与免疫,炎症和精神疾病有关.
研究的目的:
- 审查母亲的压力和乙醇暴露对肠道微生物群的影响.
- 检查对后代免疫系统和心理健康的后果.
- 为了探索潜在的肠-大脑轴干预.
主要方法:
- 在PubMed和Scopus的综合文献搜索.
- 包括从20世纪90年代到现在的临床前和人体研究.
- 专注于关键词:母亲的压力,乙醇,肠道微生物群,肠-大脑轴,抑郁症.
主要成果:
- 母亲肠道微生物群的改变会影响后代的免疫力和炎症.
- 产前压力和乙醇暴露会加剧肠道失调.
- 综合作用增加后代对抑郁症的易感性.
结论:
- 受到压力和乙醇影响的孕产妇肠道失调有助于后代的免疫功能障碍和炎症.
- 这可能会增加后代患抑郁症的风险.
- 针对母亲的肠脑轴提供了新的治疗途径.
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