在宿主-病原体相互作用中的感染中二价的作用
John A D'Elia1, Larry A Weinrauch1
1Kidney and Hypertension Section, E P Joslin Research Laboratory, Joslin Diabetes Center, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
International journal of molecular sciences
|September 28, 2024
概括
像和这样的二元酸盐会影响病原体的毒性和宿主防御. 了解这些电解质相互作用对于管理免疫功能低下个体的感染至关重要,特别是结核病患者.
科学领域:
- 传染性疾病 传染性疾病
- 免疫学 免疫学 免疫学
- 生物化学 生物化学
背景情况:
- 糖尿病,病和免疫缺陷的患病率越来越高,需要了解宿主-病原体电解质相互作用.
- 二元阴离子水平显著影响免疫受损个体的宿主易感性和病原体存活率.
- 与的比率与胰岛素耐药性和结核病风险增加有关.
研究的目的:
- 审查与双价离子运输相关的病原体毒性和宿主防御机制.
- 突出自然抵抗相关巨细胞蛋白 (NRAMP) 在宿主-病原体相互作用中的作用.
- 探索像Mycobacterium tuberculosis这样的病原体如何操纵阳离子通道.
主要方法:
- 关于电解质相互作用,免疫缺陷和病原体毒性研究的文献综述.
- 分析双价离子 (,) 在宿主防御机制 (如亡和自) 中的作用.
- 检查哺乳动物和病原体NRAMP在离子运输中的功能.
主要成果:
- 与相对的宿主细胞水平影响胰岛素抵抗和结核病风险.
- 双重阴离子运动对于宿主防御至关重要,诱导病原体亡或自.
- 病原体NRAMP与宿主NRAMP竞争双价离子,影响巨细胞内的病原体生存.
结论:
- 双重阴离子稳态是宿主防御和病原体毒性之间的关键战场.
- 在涉及金属离子运输的宿主-病原体相互作用中,NRAMP起着关键作用.
- 进一步研究离子通道动态对于开发针对传染病的新型治疗策略至关重要.
更多相关视频
11:58The Nematode Caenorhabditis Elegans - A Versatile In Vivo Model to Study Host-microbe Interactions
Published on: October 18, 2017
9.3K
06:43Studying Microbial Communities In Vivo: A Model of Host-mediated Interaction Between Candida Albicans and Pseudomonas Aeruginosa in the Airways
Published on: January 13, 2016
8.8K
相关概念视频
01:23Antimicrobial Proteins
945
Antimicrobial proteins are important components of the immune system. They aid the body in combating pathogens by either killing them directly or hindering their replication processes. Four main types of antimicrobial substances are interferons, the complement system, iron-binding proteins, and antimicrobial proteins.
Interferons
Interferons (IFNs) are proteins produced by lymphocytes, macrophages, and fibroblasts infected with viruses. While IFNs cannot prevent viruses from entering and...
Interferons
Interferons (IFNs) are proteins produced by lymphocytes, macrophages, and fibroblasts infected with viruses. While IFNs cannot prevent viruses from entering and...
945
01:09Complexation Equilibria: Factors Influencing Stability of Complexes
347
In complexation reactions, metal cations are the electron pair acceptors, and the ligands are the electron pair donors. The stability of the metal complexes depends primarily on the complexing ability of the central metal ion and the nature of the ligands. Generally, the complexing ability of the metal ion depends on the size and charge of the ion. As the metal ion size increases, the stability of the metal complexes decreases, provided that the valency of the metal ion and the ligands remain...
347
01:10Intracellular Movement of Viruses and Bacteria
2.8K
Intracellular bacteria and viruses often comprise a group of highly infectious pathogens that can cause several diseases. Bacterial pathogens include those belonging to the genus Rickettsia responsible for conditions such as rocky mountain spotted fever and the Mediterranean spotted fever; Chlamydia, a genus responsible for a sexually transmitted disease; Coxiella burnetii, an agent responsible for Q fever. Viral pathogens include vaccinia—a poxvirus, and herpes simplex virus—a...
2.8K
02:51Metal-Ligand Bonds
20.6K
The hemoglobin in the blood, the chlorophyll in green plants, vitamin B-12, and the catalyst used in the manufacture of polyethylene all contain coordination compounds. Ions of the metals, especially the transition metals, are likely to form complexes.
In these complexes, transition metals form coordinate covalent bonds, a kind of Lewis acid-base interaction in which both of the electrons in the bond are contributed by a donor (Lewis base) to an electron acceptor (Lewis acid). The Lewis acid in...
In these complexes, transition metals form coordinate covalent bonds, a kind of Lewis acid-base interaction in which both of the electrons in the bond are contributed by a donor (Lewis base) to an electron acceptor (Lewis acid). The Lewis acid in...
20.6K
01:19Complexation Equilibria: The Chelate Effect
472
In complexation reactions, metal atoms or cations interact with ligands to form donor-acceptor adducts called metal complexes. Ligands that bind through one donor site are monodentate, ligands with two donor sites are bidentate, and those with more than two donor sites are polydentate ligands. For example, ethylene diamine is a bidentate ligand that binds through two nitrogen donor atoms, forming a five-membered ring. EDTA is a polydentate ligand that binds through four oxygen and two nitrogen...
472
01:31Defense Against Bacterial Pathogens
1.4K
The human immune system is a complex network of cells, tissues, and organs that work together to defend the body against bacterial infections. It consists of various immune cells, each playing a specific role in the defense mechanism.
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
1.4K