循环多状巨型癌细胞,在患有癌的患者中是一种潜在的预后标志物
Ludmilla Thomé Domingos Chinen1,2, Jacqueline Aparecida Torres3, Vinicius Fernando Calsavara4
1Hcor Research Institute, São Paulo 04004-030, Brazil.
International journal of molecular sciences
|September 28, 2024
概括
通过液体活检检测到的循环多子巨型癌细胞 (PGCC) 表明癌症存活率较低. 这一发现凸显了PGCCs作为指导癌症治疗的潜在预后标志物.
科学领域:
- 在瘤学瘤学.
- 癌症生物学 癌症生物学
- 临床诊断 临床诊断 临床诊断
背景情况:
- 多倍体巨型癌细胞 (PGCCs) 已知具有耐治疗性.
- 检测循环PGCC的临床实用性在很大程度上仍未得到研究.
研究的目的:
- 为了确定血液中是否可以检测到循环的PGCC.
- 评估各种癌症中循环PGCCs的预后价值.
主要方法:
- 对228名癌症患者 (结肠,胃,NSCLC,乳腺,门,脏) 的回顾性研究.
- 使用ISET®液体活检和细胞病理学检测PGCC.
- 平均随访时间为44.74个月.
主要成果:
- 在20.18%的患者中检测到PGCC (46/228).
- 在非转移性病例中,检测率为14.47%,在转移性病例中为29.85%.
- 循环中的PGCC存在与较差的整体存活率有显著的相关性.
结论:
- 循环中的PGCC可以通过液体活检检测到.
- PGCCs显示出作为癌症预后生物标志物的显著潜力.
- 对抗PGCC疗法和预后应用的进一步研究是有必要的.
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