代谢功能障碍相关的脂肪性肝病 (MASLD) 和儿童糖尿病之间的交汇途径
Maria Felicia Faienza1, Ilaria Farella2, Mohamad Khalil2
1Pediatric Unit, Department of Precision and Regenerative Medicine and Ionian Area (DiMePre-J), Medical School, University of Bari "Aldo Moro", 70124 Bari, Italy.
International journal of molecular sciences
|September 28, 2024
概括
儿童肥胖症正在上升,增加了2型糖尿病 (T2DM) 和代谢相关脂肪性肝病 (MASLD) 的风险. 整合MRI可以改善风险儿童的诊断.
科学领域:
- 儿科内分泌学 儿科内分泌学
- 代谢障碍 代谢障碍 代谢障碍
- 肝病学 肝病学是一种肝病学.
背景情况:
- 在全球范围内,儿童肥胖率急剧上升,影响了超过3.4亿名儿童.
- 这种增加与胰岛素耐药性,2型糖尿病 (T2DM) 和代谢相关脂肪性肝病 (MASLD) 等代谢障碍有关.
- 肝硬化症的命名已经从非酒精性脂肪性肝病 (NAFLD) 演变为MASLD.
研究的目的:
- 审查儿童肥胖症的升级和肝肥胖症 (NAFLD到MASLD) 的不断变化的命名.
- 强调儿科内分泌学家在诊断T2DM儿童中MASLD的关键作用.
- 突出诊断缺陷,并提出改进的查策略.
主要方法:
- 关于儿童肥胖,T2DM和MASLD的综合文献综述.
- 分析当前的诊断挑战和查局限性.
- 建议将肝磁共振成像 (MRI) 纳入诊断协议.
主要成果:
- 儿童肥胖,T2DM和MASLD是相互关联的,并引起越来越多的健康问题.
- 在儿童T2DM群体中,现有的MASLD查和诊断方法不足.
- 肝脏MRI为提高诊断精度提供了一个有前途的补充工具.
结论:
- 在儿童T2DM中诊断MASLD的范式转变是必要的.
- 将肝脏MRI与常规检测相结合,可以提高诊断准确度.
- 这种整体方法对于高风险儿童的更好的结果至关重要.
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