抗TNF-α治疗改善了风湿性关节炎患者的微血管内皮功能障碍
Alexandru Caraba1, Oana Stancu2, Viorica Crișan3
1Third Internal Medicine, Diabetes and Rheumatology Department, University of Medicine and Pharmacy "Victor Babeș", 300041 Timișoara, Romania.
International journal of molecular sciences
|September 28, 2024
概括
爪毛囊镜检查显示了类风湿性关节炎 (RA) 患者的微血管内皮功能障碍. 抗TNF-α治疗在12个月内显著改善了这种功能障碍.
科学领域:
- 类风湿病学 类风湿病学
- 血管生物学 血管生物学
- 医疗成像医学成像
背景情况:
- 类风湿性关节炎 (RA) 与心血管疾病有关,微血管内皮功能障碍是早期指标.
- 爪毛细膜镜术提供了一种非侵入性的方法来评估微血管结构和功能.
- 内皮功能障碍是动脉样硬化发展的关键初始步骤.
研究的目的:
- 为了评估RA患者的微血管内皮功能障碍,使用指甲折毛细镜.
- 评估12个月的抗TNF-α治疗对RA微血管功能的影响.
- 为了将指甲折毛细管镜检查结果与RA疾病活性和炎症标志物相关联.
主要方法:
- 70名RA患者和70名健康对照人接受了指甲折毛细管镜检查,以测量毛细管密度 (Db, Dh, Dc).
- 关节炎患者进行了实验室测试,包括类风湿因子,抗CCP抗体,TNF-α,CRP,ESR和DAS28的疾病活性.
- 在12个月的抗TNF-α治疗后进行了随访毛细管透视和实验室评估.
主要成果:
- 在RA患者中,基线毛细血管密度 (Db, Dh, Dc) 与对照人群相比显著较低 (p < 0.0001).
- 毛细血管密度降低与RA疾病活性相关 (DAS28) 和TNF-α水平升高 (p <0.05).
- 在12个月的抗TNF-α治疗后,观察到微血管内皮功能显著改善 (p < 0.0001).
结论:
- 爪毛细镜在评估RA中的微血管内皮功能障碍方面是有效的.
- 抗TNF-α疗法对改善RA患者的微血管功能产生了积极的影响.
- 在RA患者中,微血管健康可以通过针对性治疗,如抗TNF-α药物来监测和潜在地改善.
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