甲状腺功能高和低的myxedema:一个hormetic反应?
Salvatore Sciacchitano1, Angela Napoli2, Monica Rocco3
1Department of Life Sciences, Health and Health Professions, Link Campus University, Via del Casale di San Pio V, 00165 Rome, Italy.
International journal of molecular sciences
|September 28, 2024
概括
发疹,一个胀的情况,可以悖论地发生在甲状腺功能低下症和甲状腺功能增强症. 生物电阻分析 (BIA) 显示,这是对甲状腺激素 (THs) 的荷尔蒙反应.
科学领域:
- 内分泌学 在内分泌学.
- 甲状腺学 甲状腺学
- 身体液体生理学 身体液体生理学
背景情况:
- 疹通常与严重的甲状腺功能低下症有关,但可以悖论地表现为甲状腺功能障碍症.
- 在甲状腺功能过高和甲状腺功能下降的状态中,混合的潜在机制仍然不清楚.
- 已知甲状腺激素 (THs) 具有催眠作用,根据剂量和持续时间表现出两相反应.
研究的目的:
- 用生物电阻分析 (BIA) 来研究甲状腺功能障碍中的体液分布.
- 探索hormesis在高甲状腺症和低甲状腺症中疹发作的潜在作用.
- 评估BIA在评估不同甲状腺功能状态的体液组成中的实用性.
主要方法:
- 通过生物电阻分析 (BIA) 分析体液分布.
- 这项研究包括103名甲状腺患者,按功能状态分类 (甲状腺,亚临床,明显的甲状腺功能障碍,严重的甲状腺功能障碍).
- 患者组和euthyroid对照组之间的BIA参数的比较.
主要成果:
- 与甲状腺控制组相比,亚临床甲状腺功能障碍中BIA参数没有变化.
- 在明显的甲状腺功能障碍和严重的甲状腺功能低下症中观察到BIA参数的显著变化.
- 甲状腺功能障碍症的体液组成变化比甲状腺功能障碍症更明显,这表明对THs的荷尔蒙反应.
- BIA对于监测明显和严重的甲状腺功能障碍是有价值的,但不是亚临床的.
结论:
- 甲状腺功能低下症和甲状腺功能增强症中的myxedema代表了对甲状腺激素 (THs) 的hormetic类型反应.
- 生物电阻分析 (BIA) 是评估和监测严重甲状腺功能障碍的体液组成的有用工具.
- 关于体液组成的亚临床甲状腺疾病评估,BIA的价值有限.
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