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Updated: Jun 11, 2025

Assessing Cellular Target Engagement by SHP2 PTPN11 Phosphatase Inhibitors
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聚胺通路抑制剂 DENSPM 抑制了花红细胞瘤细胞系中的脂质代谢

Hans K Ghayee1, Kaylie A Costa2, Yiling Xu1

  • 1Department of Medicine, Division of Endocrinology, College of Medicine, University of Florida and Malcom Randall VA Medical Center, Gainesville, FL 32608, USA.

International journal of molecular sciences
|September 28, 2024
PubMed
概括

糖酸脱酶亚单元B (SDHB) 突变驱动了染细胞瘤 (PPGL) 和偏角细胞瘤 (PGL) 的发展. 一种聚胺代谢抑制剂,DENSPM,破坏脂质通路并减少PPGL细胞中的关键脂质,提供新的治疗途径.

关键词:
这就是DENSPM的意义.SDHB SDHB是什么意思帕拉格里奥马马是什么意思叶染色细胞瘤 ( pheochromocytoma) 是一种致血性细胞瘤.塑料人体中的许多人

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