一个全面的审查的桑坦基口服药物输送系统
1Department of Pharmaceutical Sciences, School of Pharmacy, College of Health and Human Sciences, North Dakota State University, Fargo, ND 58105, USA.
International journal of molecular sciences
|September 28, 2024
概括
桑坦 (XG) 是一种可生物降解的多糖,是口服药物输送系统的多功能辅助剂. 它的独特特性使其在持续释放,胃和结肠向配方中的应用成为可能.
科学领域:
- 生物化学和制药科学 生物化学和制药科学
- 聚合物科学与工程 聚合物科学与工程
背景情况:
- 赞坦 (XG) 是一种具有独特化学结构的微生物外聚糖,具有纤维素骨干和三糖侧链.
- 它具有出色的溶解性,伪塑性行为,在广泛的温度,pH值和盐度范围内具有稳定性.
- XG是生物相容,可生物降解和无毒的,使其成为制药应用的有希望的候选者.
研究的目的:
- 在过去的十年中,审查香丹 (XG) 和其衍生品在口服药物输送系统中的应用.
- 讨论与药物输送相关的XG的来源,生产和物理化学特性.
- 突出XG在持续释放,胃缩和结肠向药物输送系统中的作用.
主要方法:
- 文献综述侧重于过去10年发表的关于口服药物输送中的香草的研究.
- 对XG的物理化学性质的分析,包括其风湿性行为,稳定性和生物相容性.
- 检查XG作为各种口服剂型 (如平板,纳米粒子,微粒子和水凝) 的矩阵成分的使用情况.
主要成果:
- 赞坦的伪塑性和稳定性使其在受控药物释放配方中更容易使用.
- 它的特性允许通过延长胃停留时间来发展胃养系统.
- 由于其在上部胃肠道中对降解的抵抗力,XG显示了针对结肠的药物输送的潜力.
结论:
- 赞坦是一种高度适应的生物聚合物,用于先进的口服药物输送系统.
- 它的化学结构允许修改,以根据特定的药物输送要求量身定制性能.
- 通常与其他聚合物结合使用的XG是开发有效的持续释放,胃缩和结肠向配方的有价值辅料.
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