人类尿道微生物群中的失生症可能区分患有膀癌的患者
Julie A Vendrell1, Simon Cabello-Aguilar1,2, Romain Senal1,3
1Laboratoire de Biologie des Tumeurs Solides, Département de Pathologie et Oncobiologie, CHU Montpellier, Université de Montpellier, 34295 Montpellier, France.
International journal of molecular sciences
|September 28, 2024
概括
尿路微生物群可能成为膀癌的新生物标志物. 这项研究发现,癌症患者的微生物多样性显著降低,特定属的丰富性增加,如Rhodanobacter,这表明诊断潜力.
科学领域:
- 微生物学 微生物学
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 在瘤学瘤学.
背景情况:
- 对膀癌的非侵入性诊断方法越来越感兴趣.
- 尿路微生物群是用于疾病检测的新生物标志物的潜在来源.
研究的目的:
- 为了研究与健康对照组相比,膀癌患者的尿道微生物群组成.
- 为了识别与膀癌相关的特定微生物特征.
主要方法:
- 利用了16S rRNA基因的八个超变区的下一代测序 (NGS).
- 分析了30名膀癌患者和32名健康对照者的尿道微生物组合.
- 在属级别进行了差异性丰度分析.
主要成果:
- 膀癌患者的微生物多样性明显较低.
- 在癌症患者中,五个属 (Rhodanobacter,Cutibacterium,Alloscardovia,Moryella,Anaeroglobus) 的数量显著增加.
- 罗达诺菌在癌症患者中显著存在,但在健康对照中不存在;40个属,包括Lactobacillus,在癌症患者中减少了丰度.
结论:
- 特定的尿路微生物种群在膀癌中表现出改变的丰富性.
- 这些发现表明,尿路微生物群是用于诊断膀癌的潜在生物标志物.
- 需要进一步的研究来探索这些微生物在膀癌病原和治疗应用中的作用.
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