长期COVID的血液供应病理生理微循环机制
1Medical Informatics and Biomedical Imaging (MIBI) Laboratory, Faculty of Medicine, School of Health Sciences, University of Thessaly, Biopolis Campus, 41500 Larissa, Greece.
长期COVID症状可能源于组织血液供应减少,通过微血管损失和血液动力学减少量化. 这种血流中断导致缺氧和营养不良,解释了COVID后持续的疾病.
科学领域:
- 生理学 生理学 生理学
- 病理生理学 病理生理学
- 医学科学 医学科学 医学科学
背景情况:
- 长期COVID是由急性COVID-19后持续的症状来定义的.
- 上一篇 长期COVID机制缺乏定量测量和基本法律.
- 这项研究为长期COVID病理生理学提供了一个框架,该框架基于血液供应剥夺和流量扩散.
研究的目的:
- 提出长期COVID病理生理学的定量框架.
- 研究血液供应减少在长期COVID中的作用.
- 为了将微血管损失和血液动力学变化与长期COVID症状联系起来.
主要方法:
- 编制的病例控制研究,比较后COVID患者和对照.
- 量化微血管损失 (ML) 使用血管密度降低,叶无血管区扩大,毛细血管密度降低和透血管减少的百分比.
- 通过结合ML和血液动力学下降 (HD) 来估计组织血液供应减少 (SR).
主要成果:
- 在COVID后的患者中,微血管损失显著 (平均VDR 16%,FAZE 31%,CDR 14%,PPVR 21%).
- 在COVID后的患者中,血液动力学平均下降率为37%.
- 估计血液供应减少达到了47%,导致缺氧和营养不良,解释了各种长期COVID症状.
结论:
- 外周组织血液供应的中断被认为是长期COVID的主要原因.
- 微血管损失和血液动力学下降显著导致血液供应减少.
- 这种机制为各种各样的长期COVID症状提供了定量解释.
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