长期COVID-19综合征中的胰岛素抵抗
Dana Emilia Man1,2, Minodora Andor3, Valentina Buda4
1Department VI-Cardiology, University Clinic of Internal Medicine and Ambulatory Care, Prevention and Cardiovascular Recovery, "Victor Babes" University of Medicine and Pharmacy, 3000041 Timisoara, Romania.
Journal of personalized medicine
|September 28, 2024
概括
长期COVID-19综合征显著增加了以前非糖尿病患者患糖尿病和胰岛素抵抗的风险. 这突显了SARS-CoV-2感染的代谢影响,需要综合护理方法.
科学领域:
- 内分泌学和新陈代谢学
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
背景情况:
- 全球范围内,COVID-19大流行导致了严重的健康问题和财务损失.
- 心脏代谢障碍是与严重的COVID-19和更高的死亡率相关的关键并发症.
- 长期COVID-19综合征是指急性SARS-CoV-2感染后持续的症状.
研究的目的:
- 评估长期COVID-19综合征与胰岛素耐药性发展之间的关系.
- 为了评估之前非糖尿病患者在SARS-CoV-2感染后的代谢变化.
主要方法:
- 对143名住院的非糖尿病COVID-19患者进行前性观察研究.
- 在入院后的0,4个月和12个月收集临床和准临床数据.
- 测量血糖,胰岛素,C-,BMI,hs-CRP和ESR;进行了静脉注射阿金刺激试验.
主要成果:
- 超过三分之一 (30.7%) 的患者患有长期COVID-19综合征.
- 75%的长期COVID-19患者在急性感染一年内发展为糖尿病.
- 在1年内,增加的BMI (>30 kg/m2) 和增加的血糖水平之间存在显著的关联;注意到胰岛素耐药性.
结论:
- 长期COVID-19综合征是发展胰岛素抵抗和糖尿病的重要危险因素.
- 在呼吸系统症状之外,SARS-CoV-2感染具有广泛的代谢影响.
- 针对呼吸和代谢方面的整体管理策略对于长期COVID-19患者至关重要.
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