牙周炎患者的牙损失-轻度认知障碍的危险因素:系统性审查和元分析
Bhawna Agarwal1, Maria Eleonora Bizzoca2, Gennaro Musella2
1School of Medicine and Dentistry, University of Central Lancashire, Preston PR1 2HE, UK.
Journal of personalized medicine
|September 28, 2024
概括
牙周病和牙脱落可能会增加50岁以上成年人轻度认知障碍的风险. 需要更多的研究来证实口腔健康和认知能力下降之间的联系.
科学领域:
- 口腔健康和认知功能
- 系统性炎症和神经健康
背景情况:
- 牙周病和牙脱落是轻度认知障碍 (MCI) 的潜在危险因素.
- 机制可能涉及全身炎症,直接的神经效应,营养不良或神经感官输入减少.
- 脑缩是这些因素的潜在后果.
研究的目的:
- 系统地审查有关牙周病,牙脱落和轻度认知障碍之间的联系的现有文献.
- 检查支持口腔健康状况与认知衰退之间的关联的证据.
主要方法:
- 使用PEO框架进行系统审查.
- 搜索了Embase,Medline,DOSS,谷歌学者,并进行了手动搜索,直到2023年4月.
- 使用纽卡斯尔-太华尺度评估研究质量.
主要成果:
- 慢性牙周炎和牙脱落,单独或联合,与50岁以上成年人轻度认知衰退的风险增加有关.
- 有证据表明,牙周炎和牙脱落有助于增加MCI和痴呆的风险.
- 目前支持这种关联的证据尚未强大.
结论:
- 需要进一步进行精心设计的研究,以调查牙周病,牙脱落和认知衰退之间的联系.
- 对于未来在这一领域的研究,需要更长的随访时间.
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