影响意图分享多基因癌症检测结果在社区医院设置中的意图的因素
Wamia Siddiqui1, Joel E Pacyna1, Sean M Phelan2
1Biomedical Ethics Research Program, Mayo Clinic, Rochester, MN 55905, USA.
Journal of personalized medicine
|September 28, 2024
概括
许多癌症患者打算与家人分享遗传性癌症查结果,但有些人犹. 了解这些决定是支持不同社区基因癌症风险评估的关键.
科学领域:
- 遗传学 遗传学 是一个
- 在瘤学瘤学.
- 公共卫生 公共卫生
背景情况:
- 多基因,多癌症遗传性癌症风险查为患者及其家人提供了好处.
- 将这些查扩展到不同的环境中,对于公平的癌症预防和治疗至关重要.
- 对于接受基因癌症查的不同人群的影响和支持需求的研究有限.
研究的目的:
- 检查患者对与风险家庭成员分享遗传查结果的观点.
- 了解影响分享或隐遗传性癌症风险信息决定的因素.
- 为支持不同社区级联基因测试的战略提供信息.
主要方法:
- 在接受多基因,多癌症风险查的多种种族样本癌症患者中进行了一项调查.
- 评估了患者与家人分享基因组查结果的意图.
- 分析了影响分享结果决定的因素.
主要成果:
- 观察到分享结果的意图很高,但意图因家庭成员类型而异.
- 超过四分之一的参与者对结果不确定或打算向至少一个处于风险的家庭成员隐结果.
- 当参与者发现分享没有好处时,分享的意图较低,特别是在兄弟姐妹与儿童相比.
结论:
- 了解患者关于分享遗传癌症查结果的决定对于支持级联测试至关重要.
- 临床医生需要解决影响结果共享的因素,以确保公平获得遗传癌症风险评估.
- 支持不同患者群体分享结果可以帮助减少癌症治疗结果的差异.
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