溶解油促进头发生长的影响及其与肠道微生物群的相关性
Jihee Kim1, Jinho An1, Yong-Kwang Lee2
1Department of Pharmacy, College of Pharmacy, Sahmyook University, Seoul 01795, Republic of Korea.
Pharmaceuticals (Basel, Switzerland)
|September 28, 2024
概括
溶解石油 (SSO) 在治疗雄性发症方面表现有前途. 口服SSO可显著促进毛发生长,并积极调节小鼠的肠道微生物群.
科学领域:
- 皮肤病学和微生物学
- 自然产品研究自然产品研究
背景情况:
- 雄激素性脱毛症影响两性,目前的治疗有副作用.
- 自然产品提取物和肠道微生物群调节是新兴的研究领域.
- 西伯利亚鱼油 (SSO) 具有营养和抗炎性质,但其对脱发的影响尚不清楚.
研究的目的:
- 为了研究溶解油 (SSO) 在促进头发生长方面的有效性.
- 为了确定SSO对调节肠道微生物群组成的影响.
- 探索SSO,头发生长标志物和肠道微生物组之间的关系.
主要方法:
- C57BL/6小鼠被局部用蒸水,SSO或米诺克西迪尔治疗,或口服SSO治疗4周.
- 组织病理学分析评估了毛囊数量和直径.
- 免疫组织化学评估了β-catenin和ERK-1表达;进行了微生物组分析.
主要成果:
- SSO治疗显著增加毛囊数量 (p < 0.001) 和毛囊直径 (p < 0.05).
- 口服SSO上调了与头发生长相关的标记物β-catenin和ERK-1.
- 减少肠道微生物群的丰富性与头发生长标志物有负相关性.
结论:
- 口服溶解油 (SSO) 有效促进头发生长.
- SSO影响头发生长途径,并积极调节肠道微生物群.
- SSO代表了一种潜在的自然治疗药物,用于安卓发症.
相关概念视频
01:50What is Monogastric Digestion?
70.9K
The human body contains a monogastric digestive system. In a monogastric digestive system, the stomach only contains one chamber in which it digests food. Several other animal species also have monogastric digestive systems, including pigs, horses, dogs, and birds. This chapter, however, focuses on the human digestive system.
70.9K
01:06Multipotency and Niche of Bulge Stem Cell
3.5K
A hair follicle or HF is a small part of the skin that produces the hair shaft. Paul Gerson Unna was the first to observe a bulge in the human hair follicle's outer root sheath (ORS). The bulge is present between the sebaceous gland and the arrector pili muscle and is the niche for hair follicle stem cells (HFSCs). The bulge is also a niche for melanocyte stem cells, and their loss results in graying of hair. The HFSCs express Sox9 and Lhx2, which help them maintain stemness and prevent...
3.5K