发展,稳定性和in vitro/in vivo研究的挥发性油皮克林乳液稳定改性珀
Maomao Zhu1, Zhonghuan Qu2, Yanjun Yang1
1Innovation Center for Industry-Education Integration of Pediatrics and Traditional Chinese Medicine, State Key Laboratory of Natural Medicines, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 211198, China.
Pharmaceuticals (Basel, Switzerland)
|September 28, 2024
概括
中国药用粉末使用皮克林乳液 (PE) 技术稳定挥发性油. 改性珀基PE (MAPE) 增强了Acorus tatarinowii挥发性油 (ATVO) 的稳定性和生物可用性,提供了一种新的配方方法.
科学领域:
- 制药科学 制药科学
- 材料科学 材料科学 材料科学
- 传统中国医药 传统中国医药
背景情况:
- 传统的挥发性油稳定方法通常需要大量的辅助剂,限制了应用.
- 皮克林乳液 (PE) 提供了使用颗粒稳定剂的替代稳定策略.
- 中国药用粉末为PE稳定提供了一种全新的综合药物辅助剂方法.
研究的目的:
- 为了提高挥发性油的稳定性,使用Pickering乳液 (PE) 稳定改性中药粉.
- 为了评估Acorus tatarinowii挥发性油 (ATVO) 在改性珀-PE (MAPE) 中的稳定性,体外释放和药理动力学.
主要方法:
- 珀表面的修改,以创建一个颗粒稳定剂.
- 使用改性珀建造一个装有ATVO的油在水PE.
- 在暴露于光线下分析MAPE稳定性 (氧化值,胺含量,挥发性成分分析).
- 在体外释放研究和MAPE与自由ATVO的药理动力学评估.
主要成果:
- 与自由ATVO相比,MAPE的过氧化物含量和malondialdehyde含量显著降低.
- 在MAPE中,挥发性成分的含量和成分仍然更接近未经处理的ATVO.
- MAPE在体外显示了关键成分 (β-asarone,α-asarone) 的快速和更高的释放.
- 药理动力学研究表明,MAPE的生物可用性得到改善.
结论:
- 修改的珀基皮克林乳液 (MAPE) 有效地稳定了Acorus tatarinowii挥发性油 (ATVO).
- 与免费ATVO相比,MAPE提供了增强的稳定性,受控释放和改善的生物利用性.
- 这项研究介绍了一种基于中国医学的独特策略,用于稳定固体配方中的挥发性油.
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