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银和金纳米粒子作为有效的抗菌剂的全面审查

Ricardo Aguilar-Garay¹, Luis F Lara-Ortiz², Maximiliano Campos-López¹

¹Clean Technologies, Environmental Process Development and Green Engineering Laboratory, Department of Environmental Systems Engineering, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Mexico City 07738, Mexico.

Pharmaceuticals (Basel, Switzerland)

|September 28, 2024

概括

黄金和白银纳米颗粒显示出对抗性细菌具有显著的抗菌特性. 标准化它们的合成和测试对于开发新的抗微生物疗法至关重要.

科学领域:

纳米技术纳米技术
材料科学材料科学材料科学
生物医学研究生物医学研究

背景情况:

抗生素耐药性是一个日益增长的全球健康威胁.
金属纳米粒子 (NP),特别是金 (Au) 和银 (Ag),具有强大的抗菌能力.
自2006年以来,针对抗微生物应用的Au和AgNP的研究已大幅扩大.

研究的目的:

审查和综合研究AU和AgNP的抗菌疗效.
探索这些NP的合成方法,形态特性和作用机制.
突出需要在NP研究中进行标准化,用于临床翻译.

主要方法:

对2006年至2023年间发表的研究进行了全面的文献综述.
在领先的纳米技术,材料科学和生物医学期刊研究的分析.
检查NP合成,形态,最小抑制度 (MIC),最小杀菌度 (MBC) 和对格拉姆阳性和格拉姆阴性细菌的有效性数据.

主要成果:

Au 和 Ag NPs 已证实对一系列细菌具有抗菌功效.
像大小,形状和表面电荷这样的NP特征极大地影响抗菌活性.
现有的文献证实了Au和AgNP作为抗菌剂的潜力.

结论:

Au和AgNP是开发新型抗菌剂的有希望的候选者.
合成,MIC测试和报告的标准化对于可复制性和临床应用至关重要.
进一步的研究和标准化将加速针对抗生素耐药性病原体的基于NP的策略的开发.

关键词:

在Ag纳米粒子中.在AU纳米粒子.具有抗菌性质的抗菌性质.抗生素耐药性抗生素耐药性细菌感染细菌感染最低杀菌度 (MBC) 是指最小的杀菌度.最低抑制度 (MIC) 是指最小的抑制度.纳米粒子合成的方法纳米技术是纳米技术.

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