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酸通过作用于JAK/STAT信号通路来减轻辐射诱导的免疫损伤

Mingyue Huang¹, Anping Ye^1,2, Haoyu Zhang¹

¹Department of Pharmaceutical Sciences, Beijing Institute of Radiation Medicine, Beijing 100850, China.

Pharmaceuticals (Basel, Switzerland)

|September 28, 2024

概括

酸 (FA) 通过维护免疫细胞功能和促进造血复原,保护免疫细胞免受辐射损伤. 这项研究表明,FA调节JAK/STAT通路,减少炎症并增强辐射后的血细胞产生.

科学领域:

辐射生物学辐射生物学
免疫学免疫学免疫学
药理学药理学是指药理学的学科.

背景情况:

辐射暴露严重破坏了造血和免疫系统.
了解辐射保护机制对于减轻长期健康影响至关重要.

研究的目的:

研究ferulic acid (FA) 作为一种防辐射剂,用于防止辐射引起的免疫损伤.
阐明FA的保护作用背后的分子机制.

主要方法:

C57BL/6J小鼠接受了辐射 (6.0 Gy ⁶⁰Co γ) 并接受了FA (25-100 mg/kg/d) 的治疗.
评估了周围血液细胞,淋巴细胞,骨髓原始细胞,并进行了全基因组转录组测序.
评估了血清标记物,炎症性细胞因子和JAK/STAT通路蛋白.

主要成果:

治疗FA显著降低了氧化应激标志物 (甲) 和增加了抗氧化剂水平 (catalase,β-尼古丁胺胺腺因二核酸).
FA增强了造血干细胞/原始细胞 (多能和常见的淋巴细胞原始细胞) 和改善了血液细胞计数 (WBC,红细胞,血红蛋白).
转录组分析显示,FA逆转了辐射诱导的免疫和炎症基因表达,抑制了IL-6,JAK1,JAK2和STAT3.

结论:

酸在造血和免疫功能上表现出显著的辐射保护作用.
通过调节JAK/STAT信号通路,FA减轻了辐射引起的损伤.
FA具有作为治疗辐射伤害管理的治疗剂的潜力.

关键词:

老化的老化衰老的老化铁酸是什么意思铁酸是什么意思免疫系统受伤免疫系统受伤这是一种炎症炎症炎症炎症.电离辐射辐射的电离辐射.

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