(Myrtus communis) L. 精油表现出对冠状病毒的抗病毒活性
Dar-Yin Li1, Matthew G Donadu2,3, Taylor Shue1
1Laboratory of Biochemical Pharmacology, Department of Pediatrics, Center for ViroScience and Cure, Emory University School of Medicine, and Children's Healthcare of Atlanta, 1750 Haygood Drive, Atlanta, GA 30322, USA.
Pharmaceuticals (Basel, Switzerland)
|September 28, 2024
概括
精油 (MEO) 对常见的人类冠状病毒HCoV-229E和HCoV-OC43.3具有强大的抗病毒活性. 这种天然疗法在低细胞毒性下表现出有效性,为人类冠状病毒感染提供了潜在的新疗法.
科学领域:
- 病毒学 病毒学
- 自然产品化学 自然产品化学
- 抗病毒研究 抗病毒研究
背景情况:
- 人类冠状病毒对全球健康构成重大威胁,需要新的抗病毒策略.
- 随着COVID-19的流行,人们迫切需要针对新出现的冠状病毒进行有效的治疗.
- 存在有限的抗病毒选择,推动对自然产品治疗潜力的研究.
研究的目的:
- 评估一种来自Myrtus communis* L. (MEO) 精油对人类冠状病毒的抗病毒功效.
- 为了比较MEO的活性与FDA批准的抗病毒药物,如Remdesivir和Nirmatrelvir.
- 评估MEO的化学成分,抗氧化活性和细胞毒性.
主要方法:
- 气体染色学和质谱学被用来确定MEO的化学成分.
- 使用细胞活力试验 (PrestoBlue) 对感染HCoV-229E和HCoV-OC43.3的Huh7.5细胞进行抗病毒活性评估.
- 在HEK293T/17和Huh7.5-AT细胞中使用人工细菌染色体质粒和病毒样颗粒研究了病毒复制,进入和组装/退出.
主要成果:
- 在Huh7.5细胞中,MEO对HCoV-229E和HCoV-OC43表现出显著的抗病毒功效,细胞毒性较低.
- 针对这些特定菌株,MEO的疗效与雷梅西维尔和涅玛特里尔维尔相当或高于雷梅西维尔和涅玛特里尔维尔.
- 在测试的试验中,MEO没有显示出针对SARS-CoV-2的显著抗病毒活性,包括病毒复制和入口.
- 在MEO中检测到轻微的抗氧化活性.
结论:
- *Myrtus communis* L.精油 (MEO) 对常见的人类冠状病毒 (HCoV-229E,HCoV-OC43) 具有强大的抗病毒特性.
- MEO代表了一个有前途的自然产品候选人,用于开发人类冠状病毒感染的替代治疗方法.
- 需要进一步的研究来探索MEO对其他冠状病毒菌株的治疗潜力及其作用机制.
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