来自树和香柏树的细胞提取物显示对罩病毒的抗病毒活性
Takashi Furukawa1, Ayumu Inagaki2, Takeshi Hatta3
1Department of Health Science, School of Allied Health Sciences, Kitasato University, 1-15-1, Kitasato, Sagamihara 252-0373, Japan.
Microorganisms
|September 28, 2024
概括
树和雪松的细胞提取物显示出强大的抗病毒活性,对抗像phi6菌这样的包裹病毒. 这些天然提取物在30秒内有效地使病毒失活,突出了它们作为抗病毒剂的潜力.
科学领域:
- 自然产品化学 自然产品化学
- 病毒学 病毒学
- 抗病毒剂 抗病毒剂
背景情况:
- 从树 (Chamaecyparis obtusa) 和香柏树 (Cryptomeria japonica) 的细胞提取物 (CE) 进行了针对其抗病毒功能的研究.
- 菌体phi6 (包裹) 和MS2 (非包裹) 被用作人类病毒的替代模型.
研究的目的:
- 评估来自C. obtusa和C. japonica的CE的抗病毒功效.
- 确定这些植物衍生提取物作为天然抗病毒剂的潜力.
主要方法:
- 来自C. obtusa和C. japonica的CE的化学成分分析.
- 使用不同CE度和暴露时间的phi6和MS2菌体进行抗病毒检测.
- 确定日志减少值 (LRV) 以量化病毒失活.
主要成果:
- 来自C. obtusa的CE含有丰富的 terpinen-4-ol,α-terpinyl乙酸和 bornyl 乙酸.
- 来自C. japonica的CE含有丰富的 terpinen-4-ol和α-pinene.
- 这两种CE都表现出强大的抗病毒活性对抗phi6菌体,在25%度下,在30秒内达到LRV>4,达到25%度.
- 在12.5%CE度以下,对phi6的抗病毒活性会丧失.
- 没有观察到针对非包裹的MS2菌的抗病毒活性.
结论:
- 来自C. obtusa和C. japonica的CE具有显著的抗病毒功效,可以对抗包裹病毒.
- 这些发现表明,树和雪松提取物作为天然抗病毒剂的潜力,特别是对于包裹的病毒标.
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