作为健康益处促进者的候选益生菌乳杆菌及其后生菌
Lili Dobreva1, Nikoleta Atanasova1, Petar Donchev1
1The Stephan Angeloff Institute of Microbiology, Bulgarian Academy of Sciences, 26 Acad. G. Bonchev Str., 1113 Sofia, Bulgaria.
Microorganisms
|September 28, 2024
概括
这项研究研究了四种Lactobacillus菌株的益生菌潜力,发现它们可以抑制有害微生物和清除自由基. 他们的后生物对白血病细胞产生了多种影响,这表明了未来的治疗应用.
科学领域:
- 微生物学 微生物学
- 益生菌 益生菌 益生菌
- 免疫学 免疫学 免疫学
背景情况:
- 乳酸菌种因其健康益处和保护机制而闻名.
- 研究微生物组恒温的新型菌株对于开发向益生菌至关重要.
研究的目的:
- 为了评估四种乳杆菌菌株的体外益生菌潜力:乳杆菌植物菌株L6和F53,Ligilactobacillus salivarius 1和乳杆菌 helveticus 611.
- 评估它们的抗菌,抗真菌,抗氧化和细胞毒性活动,以潜在地作为保护培养和治疗应用.
主要方法:
- 对各种病原体进行了抗菌和抗真菌分析.
- 使用DPPH和ABTS测定测量了自由基清除能力.
- 使用电子偏磁共振光谱学研究了抗氧化剂的潜力.
- 用MTT测定和SEC-FPLC分析评估了后生物分量的细胞毒性对K562白血病细胞的影响.
主要成果:
- 这四种菌株都表现出广泛的抗菌和抗真菌活性,抑制了诸如金黄色葡萄球菌和大肠杆菌等病原体.
- 这些菌株表现出特定于菌株的自由基清除能力.
- 来自L. salivarius 1的后生物分离物显示,对K562细胞的半最大抑制度 (IC50) 为46.15 mg/mL.
- 电子磁共振谱学阐明了解热化菌株中抗氧化潜力的分子基础.
结论:
- 选择的乳酸菌具有显著的体外功能,包括抗微生物和抗氧化特性.
- 这些菌株显示出开发向益生菌和潜在治疗剂的前景.
- 在临床应用之前,需要对后生物生产和安全性评估进行进一步的研究.
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