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基于统计的优化修改的Mangifera indica水果粉作为药品片剂辅助剂的替代品
Prin Chaksmithanont1, Ketsana Bangsitthideth2, Kwanputtha Arunprasert2
1Department of Industrial Pharmacy, Faculty of Pharmacy, Silpakorn University, Nakhon Pathom 73000, Thailand.
Polymers
|September 28, 2024
概括
修改的果粉被优化为制药用途. 这种新型的辅助剂显示出作为一种粘合剂,分解剂和稀释剂的潜力,与未经修改的粉相比,它提供了更好的流动和膨胀特性.
科学领域:
- 制药科学 制药科学
- 材料科学 材料科学 材料科学
- 食品化学 食品化学
背景情况:
- 制药配方在很大程度上依赖于药片生产的辅助剂.
- 像果果这样的自然资源为开发新型,可持续的辅助剂提供了潜力.
- 优化粉修饰对于增强其功能性质至关重要.
研究的目的:
- 为了优化从Mangifera indica (果) 果实中获得的改性粉,用于制药片剂辅助剂.
- 为了研究粉修饰的酸水解和微波辅助预凝化.
- 为了评估修改的果粉的流动性,压缩性和膨胀性质.
主要方法:
- 计算机辅助优化使用三级因数设计用于水解和化前参数 (时间,温度).
- 改性粉对关键功能性质的表征.
- 结构分析以确认成功修改粉.
主要成果:
- 优化水解:在56.4°C3.8小时;优化前凝化:在150°C3分钟.
- 改性粉表现出更好的流动性,压缩性和显著增强的膨胀特性 (高达3.95倍).
- 优化的水解粉显示出优于未经修改的粉的性能和与常规辅助剂相比较的特性; 前凝化粉显示出优异的流量和压缩增强.
结论:
- 实验的软件辅助设计使得果粉修饰的数据驱动优化成为可能.
- 优化改性果粉显示出作为多功能制药辅助剂 (粘合剂,分解剂,稀释剂) 的巨大潜力.
- 这项研究强调了利用水果粉作为制药应用中的可持续替代品的可行性.
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