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基于多莉花) 乳的反应性氧物种受管制结合物,用于同时输送多克索鲁比和多克萨

Jyoti Verma¹, Vishal Kumar^1,2, Carl-Eric Wilen²

¹Pharmaceutical Sciences Laboratory, Faculty of Science and Engineering Åbo Akademi University, Biocity, Tykistökatu 6A, 20520 Turku, Finland.

|September 28, 2024

概括

这项研究开发了一种对刺激敏感的聚合物药物合物,用于向癌症治疗. 接近红外线的光会触发微粒中的多克索鲁比辛和多塞塔克塞尔的释放,增强癌细胞死亡,毒性最小.

科学领域:

生物医学工程生物医学工程
材料科学材料科学材料科学
在瘤学瘤学.

背景情况:

选择性药物输送在癌症治疗中至关重要,以尽量减少细胞毒剂的副作用.
开发刺激响应系统允许在瘤部位控制释放抗癌药物.

研究的目的:

为了合成和表征一种新型刺激敏感的聚合物药物合物,用于向癌症治疗.
为了评估近红外 (NIR) 光触发的药物释放自组装小粒的疗效.
评估开发系统在乳腺癌细胞上的体外细胞毒性.

主要方法:

将多克索鲁比辛 (DOX) 和多塞塔克塞尔 (DTX) 结合到一个多聚合物中,使用一个 thioketal (TK) 链接器.
e6作为光敏感剂的附着,用于产生反应性氧物种.
结合物的自我组装成小粒 (<100 nm) 和由NIR光触发的药物释放的评估.
对MDA-MB-231乳腺癌细胞进行细胞毒性测定,有或没有NIR光照.

主要成果:

聚合物 - 药物结合体自组装成适合药物输送的.
与免费药物相比,NIR光照射显著增强了细胞释放的DOX和DTX的细胞毒性.
对焦显微镜证实了激光照射后释放的DOX的核积累.
不同于免费药物,在没有光线的情况下,米塞尔表现出微不足道的毒性.

结论:

发育的刺激敏感菌体显示出有效的向药物递送和抗癌剂 (DOX和DTX) 的释放,这些药物是由外部NIR光触发的.
该系统提供了一种有前途的策略,可以提高癌症治疗的疗效,同时降低全身毒性.
聚合物结合,刺激响应链接剂和光敏感剂的组合为先进的癌症治疗提供了一个多功能平台.

关键词:

这就是ROSOS ROS.莉花乳) 是一种多莉花乳.聚合物药物合物合物刺激的响应性刺激的响应性有针对性的药物输送.

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