磁纳米颗粒与现场的化物和基因功能化聚合物涂层在单个步骤中通过溶热过程
Romualdo Mora-Cabello1, David Fuentes-Ríos1, Lidia Gago2,3,4
1Department of Organic Chemistry, Faculty of Sciences, University of Málaga, 29071 Málaga, Spain.
Pharmaceutics
|September 28, 2024
概括
超偏磁铁氧化物纳米粒子使用溶热法与聚合物涂层进行合成,以提高稳定性和生物医学应用. 这些纳米颗粒具有出色的磁性和生物相容性,使其适用于药物输送和高热治疗.
科学领域:
- 材料科学 材料科学 材料科学
- 纳米技术 纳米技术
- 生物医学工程 生物医学工程
背景情况:
- 磁铁氧化物纳米粒子 (MNPs) 在各种科学领域越来越重要.
- 通过一步溶热方法合成MNP,使用亚酸和基因功能化聚乙烯甘醇 (PEG) 聚合物和β-环极 (βCD) 作为稳定剂.
研究的目的:
- 开发和描述具有量身定制的表面功能的新型磁性纳米粒子.
- 评估它们的磁性特性,稳定性和生物医学应用的潜力,包括药物结合和高温症.
主要方法:
- 使用PEG和βCD涂层的MNP的溶热合成.
- 使用TEM,AFM,NMR,XRD,FT-IR,MALDI和VSM进行表征.
- 评估磁性特性,在交替磁场 (AMF) 下的特定吸收率 (SAR),点击化学结合和体外细胞毒性测试.
主要成果:
- 合成的纳米粒子 (@Fe3O4-PEGs和@Fe3O4-βCD) 的直径在90-250nm之间.
- 许多MNP表现出具有高和磁化 (高达59.9emu/g) 的超偏磁性,而没有铁磁性.
- 证明了与大麻衍生物的成功点击化学结合,并在水性介质中表现出极好的分散性超过两周.
- 达到了高达51.87±2.23W/g的SAR值,并且在T84人类结肠癌细胞系中没有表现出毒性.
结论:
- 开发的磁性纳米粒子具有理想的超偏磁性质,卓越的稳定性和生物相容性.
- 它们对点击化学的易感性和证明的无毒性使得它们对各种生物医学应用非常有希望,包括向药物输送和癌症高温疗法.
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