口服凝作为液体儿科悬浮剂的替代品,由商业平板电脑组成
Monika Trofimiuk1,2, Małgorzata Sznitowska3, Katarzyna Winnicka2
1Department of Clinical Pharmacy, Medical University of Bialystok, 15-222 Bialystok, Poland.
Pharmaceutics
|September 28, 2024
概括
药房复合口服凝为儿童提供了一个儿童友好的替代品,可以替代瓦尔萨坦和坎德萨坦西莱克塞蒂尔等药物的糖. 这些凝提供了更好的口味掩饰和稳定性,建议的有效期为沙坦35天,沙坦14天.
科学领域:
- 制药技术 制药技术 制药技术
- 儿科配方 儿科配方 儿科配方
- 药物输送系统 药物输送系统
背景情况:
- 儿科口服药物往往会带来味道和管理方面的挑战.
- 糖可能很难让孩子吞下,容易溢出.
- 现有的配方可能缺乏最佳的口感和易于使用的儿科患者.
研究的目的:
- 开发和评估药房复合口服凝作为儿童使用的新型剂型.
- 与传统糖相比,提高口感并降低使用风险.
- 为了将瓦尔萨坦和坎德萨坦基莱克塞蒂尔纳入稳定的水凝配方中.
主要方法:
- 使用纤维素衍生物 (基乙纤维素,卡梅洛) 和卡博默 (carbomers) 制备了凝.
- 评估了物理特性 (一致性,粘度,感官) 和微生物稳定性.
- 瓦尔萨坦和坎德萨坦基莱克塞提尔片被粉碎并悬浮在优化的水凝基中.
- 药物的稳定性和配方变化在25°C下在35天内被监测.
主要成果:
- 用碳聚 (0.75%) 和纤维素衍生物 (2.0%) 配制的凝表现出最佳的物理和感官特性.
- 使用甲基帕拉本和酸盐确保了微生物的稳定性.
- 加入粉碎瓦尔萨坦和坎德沙坦并没有显著改变凝粘度或一致性.
- 配方在35天的储存期间显示出极小的粘度变化,特别是与糖和candesartan.
结论:
- 药房复合口服凝是儿科药物的可行和可口的替代剂型.
- 优化的碳和纤维素衍生物凝提供了合适的物理特性和稳定性.
- 建议的有效期为瓦尔沙坦的35天,德沙坦制剂的25°C的14天.
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