在缺血性中风和相关的传统中医药中的铁
Runchen Ma1, Xiaohui Sun1, Zhaofeng Liu1
1Key Laboratory of Molecular Pharmacology and Drug Evaluation, Ministry of Education, Collaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of Shandong, School of Pharmacy, Yantai University, Yantai 264005, China.
Molecules (Basel, Switzerland)
|September 28, 2024
概括
缺血性中风 (IS) 会导致严重的残疾. 本综述探讨了铁亡,IS中细胞死亡途径,以及传统中医药 (TCM) 如何通过抑制铁亡来提供新的治疗策略.
科学领域:
- 神经学 神经学
- 药理学 药理学是指药理学的学科.
- 生物化学 生物化学
背景情况:
- 在全球范围内,中风是导致死亡和残疾的主要原因.
- 由血管堵塞引起的缺血性中风 (IS) 占中风病例的70-80%.
- 在IS中细胞死亡机制包括亡,亡和铁亡,这是与铁过载和脂质过氧化相关的过程.
研究的目的:
- 审查铁质死在缺血性中风中的作用.
- 探索传统中医药 (TCM) 在减轻IS损害方面的潜力.
- 为了突出 TCMs 抑制 ferroptosis 的中风治疗.
主要方法:
- 关于中风,铁死和TCM的文献综述.
- 在缺血性中风中分析细胞死亡机制.
- 识别具有抑制铁灭的特性的TCM.
主要成果:
- 铁亡是缺血性中风中细胞死亡的关键途径.
- 重组组织等离子体激活剂 (rt-PA) 是主要的治疗方法,但具有局限性.
- 几种TCM有潜力抑制铁亡并减少与IS相关的损伤.
结论:
- 铁质在缺血性中风的发病过程中起着至关重要的作用.
- 通过向铁亡,TCM为新型中风疗法提供了一个有希望的途径.
- 对TCM的进一步研究可能会导致改善缺血性中风的治疗方法.
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