优化和合成纳米尼奥索姆用于封装Triacontanol的盒子-Behnken设计
Alfredo Amaury Bautista Solano1, Gloria Dávila-Ortiz2, María de Jesús Perea-Flores3
1Departamento de Biotecnología, Centro de Desarrollo de Productos Bióticos, Instituto Politécnico Nacional (IPN), Carretera Yautepec-Jojutla s/n-Km 85, San Isidro, Yautepec 62739, Morelos, Mexico.
Molecules (Basel, Switzerland)
|September 28, 2024
概括
这种药物是三甲醇 (triacontanol).
科学领域:
- 制药科学 制药科学
- 材料科学 材料科学 材料科学
背景情况:
- 植物生长调节剂的三甲醇具有潜在的抗炎和抗瘤作用.
- 它的治疗用途受到由于高水性而导致的溶解性和生物可用性差的阻碍.
- 涅体为封装疏水化合物提供了一个有前途的解决方案,增强药物输送.
研究的目的:
- 为了优化和合成纳米体,以有效地进行三甲醇封装.
- 为了描述发达的三甲醇载荷的体体的物理化学性质.
主要方法:
- 用薄膜水化方法与超声波相结合,合成了尼奥索姆.
- 一个盒子-Behnken设计被用于配方优化.
- 鉴定包括动态光散射,FTIR,共聚焦显微镜,SEM和TEM.
主要成果:
- 优化的阴体体 (配方14) 显示出所需的尺寸和负的泽塔电位 (-31.28 ± 1.21).
- FTIR证实了分子间相互作用,表明封装成功.
- 同焦显微镜和TEM验证了三甲醇的存在以及体的球形结构.
结论:
- 纳米体提供了一种有效的输送系统,用于疏水性三甲醇.
- 开发的阴性体配方显示出改善三甲醇治疗应用的潜力.
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