生活方式干预对多发性硬化症的影响:专注于脂肪组织
Marta Mallardo1,2, Filomena Mazzeo3, Giacomo Lus4,5
1Department of Molecular and Biotechnological Medicine, University of Naples "Federico II", 80138 Naples, Italy.
Nutrients
|September 28, 2024
概括
身体活动和营养等生活方式因素通过影响脂肪组织 (AT) 和adipokines影响多发性硬化症 (MS). 了解这些联系可能会改善多发性硬化症的治疗和患者的生活质量.
科学领域:
- 免疫学 免疫学 免疫学
- 内分泌学 在内分泌学.
- 神经科学是一个神经科学.
背景情况:
- 多发性硬化症 (MS) 是一种慢性自身免疫性中枢神经系统疾病,其病因不明,尽管炎症和免疫功能障碍是关键因素.
- 脂肪组织 (AT) 通过内分泌功能和脂蛋白分泌影响免疫反应和炎症,使其与MS等免疫疾病有关.
研究的目的:
- 审查脂肪组织和关键阿迪波金 (阿迪波涅丁,莱普丁,TNFα) 在多发性硬化症发病过程中的作用.
- 探索体育活动和营养补充的潜力,作为管理MS的非药物战略.
主要方法:
- 关于脂肪组织,脂蛋白和它们在MS中的参与的最新数据的文献综述.
- 分析体育活动和饮食管理对MS患者生活质量的影响.
主要成果:
- 脂肪组织及其分泌的阿迪波金在MS背后的炎症和免疫过程中发挥着重要作用.
- 身体活动和营养策略可以调节AT功能和阿迪波金配置文件,这可能有利于MS患者.
结论:
- 包括体力活动和饮食管理在内的生活方式干预措施是改善多发性硬化症患者生活质量的有希望的非药物治疗方法.
- 需要进一步研究生活方式,脂肪组织和MS病原体之间的相互作用.
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