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在精神性厌食症中,避免食物和厌恶目标值计算
Siri Weider1,2, Megan E Shott3, Tyler Nguyen3
1Department of Psychology, Norwegian University of Science and Technology (NTNU), 7491 Trondheim, Norway.
Nutrients
|September 28, 2024
概括
神经成像显示,有神经性厌食症 (AN) 的人在避免食物时表现出奖励和厌恶电路中的大脑活动增加,这表明厌恶目标价值处理在这种行为中发挥了作用.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 神经成像是一种神经成像.
背景情况:
- 神经性厌食症 (AN) 的特点是食物限制和体重低,但食物避免的潜在神经生物学仍然不清楚.
- 动物模型表明有条件的恐惧,涉及前带带状和核,可能会触发食物回避.
研究的目的:
- 研究神经性厌食症中避免食物的神经机制.
- 用厌恶目标价值处理原理在AN中建模食物回避.
- 为了比较AN和健康对照的女性之间的食物避免任务期间的大脑激活模式.
主要方法:
- 功能性磁共振成像 (fMRI) 用于扫描19名有AN的女性和30名健康对照.
- 参与者完成了一项食物避免任务,包括在免费竞标和强迫竞标试验期间竞价钱,以避免吃食物.
- 根据试验对试验的投标,对大脑激活进行了参数分析.
主要成果:
- 与对照组相比,AN组在自由投标试验期间在尾状核,状核,腹前环膜和轨道前皮层中显示出更大的激活.
- 在AN组中,更高的出价与尾状核反应的增加相关.
- 情绪失调和对不确定性的不耐受与在AN的自由竞标试验中与核激活相反相关.
结论:
- 在神经性厌食症中,避免食物似乎涉及特定大脑区域内的厌恶目标值计算.
- 这些发现涉及核,尾状核,前环膜和轨道前皮层在AN中避免食物的神经生物学中.
- 这项研究提供了一个神经生物学框架,通过奖励和厌恶处理的镜头来理解AN中避免食物.
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