地中海饮食调节与神经炎症相关的基因在高心血管风险的老年人中

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Javier Hernando-Redondo^1,2,3, Mireia Malcampo², Karla Alejandra Pérez-Vega^1,2

¹CIBER de Fisiopatología de la Obesidad y Nutrición, Instituto de Salud Carlos III, 28029 Madrid, Spain.

Nutrients

|September 28, 2024

概括

地中海饮食,特别是附加初橄油,可能会调节与神经退行性疾病和老年人心血管疾病风险相关的基因表达.

科学领域:

神经科学是一个神经科学.
心脏病学心脏病学
营养科学营养科学

背景情况:

心血管疾病 (CVD) 在痴呆症和神经退行性疾病 (NDD) 患者中很普遍.
神经炎症,通常与心血管疾病相关,可以破坏中枢神经系统并创造炎症环境.
地中海饮食 (MedDiet) 以其抗炎和抗氧化功效而闻名,有可能减轻这些风险.

研究的目的:

研究MedDiet干预措施对与NDD和CVD相关的基因表达标记物的影响.
在12个月内分析基因表达的变化,以应对不同的饮食模式.
为了识别由MedDiet成分调节的特定基因,如特级初橄油 (EVOO) 和坚果.

主要方法:

从134名参加PREDIMED试验的参与者的血液核细胞样本分析.
参与者被随机分配到含有EVOO的MedDiet (MedDiet-EVOO),含有坚果的MedDiet (MedDiet-Nuts) 或低脂肪控制饮食.
基因表达分析在基线和12个月后进行,重点关注交叉NDD和CVD关联的基因.

主要成果:

在MedDiet-EVOO组中观察到显著的基因表达变化,特别是对于CDKN2A,IFNG,NLRP3,PIK3CB和TGFB2.
在MedDiet-Nuts组中,TGFB2表达也发生了变化.
对比分析显示MedDiet-EVOO和对照组之间TGFB2的显著差异,以及MedDiet-坚果和对照组之间的NAMPT.

结论:

一年传统的MedDiet,特别是MedDiet-EVOO,可以调节与心血管疾病风险和NDD相关的基因表达.
这些发现凸显了MedDiet在管理高心血管风险的老年人复杂健康状况方面的潜力.
像TGFB2和NAMPT这样的特定基因似乎是这些饮食影响的关键媒介.

关键词:

地中海饮食地中海饮食心血管疾病心血管疾病神经炎症是一种神经炎症.营养基因组学营养基因组学

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