对于中枢神经系统健康的S-Adenosylmethionine (SAMe):一个系统性审查
Kyrie Eleyson R Baden1, Halley McClain1, Eliya Craig1
1School of Pharmacy, Cedarville University, Cedarville, OH 45314, USA.
Nutrients
|September 28, 2024
概括
在改善情绪和其他中枢神经系统 (CNS) 症状方面,S-adenosylmethionine (SAMe) 是有前途的. 这次系统性审查发现,SAME在大多数研究中有效,副作用轻微,但需要对中枢神经系统长期影响进行更多研究.
科学领域:
- 神经科学是一个神经科学.
- 药理学 药理学是指药理学的学科.
- 精神病学是一个精神病学.
背景情况:
- S-adenosylmethionine (SAMe) 是一种天然存在的化合物,因其有助于缓解情绪相关症状而受到研究.
- 中枢神经系统 (CNS) 的症状,包括情绪,行为和睡眠障碍,是治疗干预的常见目标.
研究的目的:
- 系统地评估S-adenosylmethionine (SAMe) 对改善中枢神经系统 (CNS) 症状的疗效和安全性.
- 为了确定SAME的最佳剂量,用于中枢神经系统相关的症状管理.
- 综合现有关于SAME对情绪,行为和睡眠影响的研究结果.
主要方法:
- 进行了基于PRISMA的系统审查,使用医学主题标题 (MeSH) 术语搜索主要数据库 (PubMed,CINAHL,Web of Science).
- 两名研究人员独立审查了文章,第三名研究人员解决了差异,在标题/摘要选和全文评估期间进行了独立审查.
- 为了确保可靠性,数据提取和包含的研究的质量评估被系统地执行.
主要成果:
- 在1881项初步研究中,36项专注于中枢神经系统征兆的高质量研究被纳入了审查.
- 在36项审查的研究中,S-adenosylmethionine (SAMe) 在24项中显示出有效性.
- 与SAME相关的不良事件主要是轻微和短暂的胃肠道障碍.
结论:
- 许多患者在接受S-adenosylmethionine (SAMe) 治疗时经历了中枢神经系统 (CNS) 症状的改善,无论是作为独立治疗还是辅助治疗.
- 这些发现支持SAME在管理情绪,行为和睡眠障碍方面的潜在实用性.
- 需要进一步的研究来阐明SAME在中枢神经系统 (CNS) 中的长期影响和最佳应用.
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