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在儿童中移植获得的食物过敏
Cristiana Indolfi1, Angela Klain1, Giulio Dinardo1
1Department of Woman, Child and of General and Specialized Surgery, University of Campania Luigi, Vanvitelli, 80138 Naples, Italy.
Nutrients
|September 28, 2024
概括
儿科移植接受者可能会患上移植获得的食物过敏症 (TAFA),通常在移植后的一年内. 早期免疫监测是管理这些过敏和改善结果的关键.
科学领域:
- 儿科过敏和免疫学
- 移植医学 移植医学 移植医学
- 免疫学 免疫学 免疫学
背景情况:
- 儿童器官移植对于末期器官衰竭至关重要.
- 移植后的过敏,特别是食物过敏 (TAFA),是儿童接受者的新兴问题.
- 儿童移植患者的免疫抑制疗法可以改变免疫功能并增加过敏风险.
研究的目的:
- 审查儿童器官移植受体中移植获得的食物过敏 (TAFA) 的最新证据.
- 了解TAFA的患病率,常见的过敏原和临床表现.
- 突出监测和管理策略的重要性.
主要方法:
- 在2024年6月25日至7月5日期间进行了全面的PubMed搜索.
- 确定了143篇文章,并在选后包括了36项研究 (回顾性,前性,横截面性,病例报告/系列).
- 审查的重点是关于儿科器官移植接受者和TAFA的研究.
主要成果:
- 肝移植接受者是主要焦点,食物过敏的患病率从3.3%到54.3%不等.
- 塔克罗利和皮质类固醇是常见的免疫抑制剂;过敏通常在一年内出现.
- 常见的过敏原包括牛奶,蛋,坚果和海鲜,观察到IgE介导和非IgE介导的反应.
结论:
- 早期和一致的免疫监测 (例如皮肤刺伤测试,IgE水平) 对于检测和管理过敏至关重要.
- 了解移植和过敏发展之间的关系对于提高儿科接受者的长期结果至关重要.
- 需要积极的管理策略来减轻TAFA的影响.
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