果蝙蝠在实验挑战时不支持雪松病毒的生产复制
Björn-Patrick Mohl1, Sandra Diederich1, Kerstin Fischer1
1Institute of Novel and Emerging Infectious Diseases, Friedrich-Loeffler-Institut, Suedufer 10, 17493 Greifswald, Germany.
Viruses
|September 28, 2024
概括
果蝙蝠中雪松河尼病毒 (CedV) 感染没有显示任何临床症状,只检测到最小的病毒RNA. 这项研究表明,CedV是研究高度致病性海尼帕病毒的安全模型.
科学领域:
- 病毒学 病毒学
- 传染性疾病 传染性疾病
- 动物感染病原体的病原体
背景情况:
- 雪松河尼帕病毒 (CedV) 是一种非致病性帕拉米克索病毒,与高度致病性亨德拉病毒 (HeV) 和尼帕病毒 (NiV) 有关.
- 由于其在人类和动物中的病原性,CedV作为研究海尼帕病毒的有价值模型.
- 了解海尼帕病毒传播和宿主易感性对于公共卫生至关重要.
研究的目的:
- 调查Rousettus aegyptiacus水果蝙蝠对Cedar henipavirus (CedV) 的年龄依赖的敏感性.
- 评估果蝙蝠中CedV感染的临床和亚临床影响.
- 评估CedV在蝙蝠中的挑战后的病毒分泌和分布.
主要方法:
- 八个不同年龄的Rousettus aegyptiacus水果蝙蝠被内鼻接种了CedV.
- 动物被监测临床症状,体温和运动活动.
- 病毒RNA在注射后2天的呼吸道,脏和拭子样本中得到量化.
主要成果:
- 在任何CedV挑战的蝙蝠中都没有观察到疾病的临床迹象.
- 在注射后2天,在上呼吸道,脏和口腔/门拭子中检测到微量病毒RNA.
- 在一些受到挑战的蝙蝠身上检测到微妙的,否则无法察觉的体温和运动变化.
结论:
- 无论年龄大小,水果蝙蝠对雪松尼病毒 (CedV) 感染的敏感性较低.
- 在这种蝙蝠物种中,CedV感染在很大程度上是无症状的,病毒复制和流失的最小.
- 这些发现支持使用CedV作为安全的模型用于henipavirus研究,同时强调需要敏感的监测方法.
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