对HSV1/2感染的分析显示,HSV-2再激活和怀孕之间存在关联
Sara Dovrat1, Adar Shabat1, Anat Yahav-Dovrat2
1National Center for Herpes, Central Virology Laboratory, Ministry of Health, Sheba Medical Center, Ramat Gan 52621, Israel.
Viruses
|September 28, 2024
概括
简单疹病毒2型 (HSV-2) 生殖器感染在女性和怀孕期间更为常见. 怀孕可能会增加HSV-2再激活或感染的风险,强调需要进一步研究.
科学领域:
- 病毒学 病毒学
- 传染性疾病 传染性疾病
- 流行病学 流行病学
背景情况:
- 简单疹病毒 (HSV-1和HSV-2) 在全球范围内广泛传播,目前尚无可治疗的治疗方法.
- 了解与HSV-1和HSV-2感染相关的独特特征和风险因素对于公共卫生至关重要.
- 以前的研究表明,根据人口统计和临床因素,感染模式的变化.
研究的目的:
- 分析和比较简单疹病毒1型 (HSV-1) 和2型 (HSV-2) 感染的流行病学和临床特征.
- 根据性别,年龄,感染部位,并发症和怀孕的影响来调查感染患病率的潜在差异.
- 确定与HSV-2生殖器感染相关的风险因素,特别是与怀孕有关的风险因素.
主要方法:
- 在以色列中央病毒学实验室 (2011-2018) 通过复杂实时PCR诊断的9189个样本的分析.
- 在谢巴医疗中心提取了287名患有生殖器HSV-1或HSV-2感染的住院女性的医疗数据.
- 在不同的人口和临床变量中对感染特征的统计比较.
主要成果:
- 在口腔面部样本中很少发现HSV-2,但与男性相比,女性生殖器损伤的发生率明显高 (p <0.05).
- 首次检测到HSV-2是在青春期左右. 在孕妇中,生殖器HSV-2感染的发生率明显高于HSV-1感染的发生率 (12.4%) (27.8%).
- 初级感染更常见的是HSV-1 (15.6%),而不是HSV-2 (3.2%).
结论:
- 生殖器HSV-2感染在女性中发生率更高,并且在怀孕期间更常见.
- 怀孕成为HSV-2重新激活或获得的潜在风险因素,需要有针对性的临床关注.
- 这些发现强调了在管理和了解HSV感染时考虑性别和妊娠状态的重要性.
更多相关视频
13:22Detection of the Genome and Transcripts of a Persistent DNA Virus in Neuronal Tissues by Fluorescent In situ Hybridization Combined with Immunostaining
Published on: January 23, 2014
18.2K
06:03Author Spotlight: Advancing Immune Monitoring in Critical Care Patients Using Whole Blood Assays
Published on: September 20, 2024
1.2K
相关概念视频
Viral Recombination
Cells are sometimes infected by more than one virus at once. When two viruses disassemble to expose their genomes for replication in the same cell, similar regions of their genomes can pair together and exchange sequences in a process called recombination. Alternatively, viruses with segmented genomes can swap segments in a process called reassortment.
Sexually Transmitted Infections
Sexually transmitted infections (STIs) are diseases transmitted primarily through unsafe sexual interactions. Bacteria, viruses, or parasites cause them and can result in severe health complications if untreated.ChlamydiaThe bacterium Chlamydia trachomatis is responsible for the disease Chlamydia, the most common STI in the United States. This peculiar pathogen requires human cells to reproduce, residing intracellularly. The initial infection often goes unnoticed because it typically does not...
Herpes
Herpes simplex type 1 (HSV‑1) is a widespread pathogen responsible for orolabial lesions. It is an enveloped, double-stranded DNA (dsDNA) virus belonging to the family Herpesviridae. Once the virus infects a host cell, its double‑stranded DNA genome is delivered into the nucleus, where a coordinated cascade of immediate‑early, early, and late gene expression directs viral DNA replication, structural protein synthesis, and virion assembly. After primary infection of epithelial cells, HSV-1...
Chickenpox
Chickenpox is an acute, highly contagious disease caused by the varicella-zoster virus (VZV), a double-stranded DNA virus belonging to the Herpesviridae family. Its transmission occurs primarily through the inhalation of respiratory droplets or direct contact with vesicular fluid from skin lesions. The incubation period typically ranges from 10 to 21 days, during which the virus replicates and disseminates through sequential phases within the host. Although generally self-limiting in children,...
Cytomegalovirus Disease
Cytomegalovirus (CMV) disease is caused by human cytomegalovirus, a double-stranded DNA virus of the Herpesviridae family. While primary CMV infection is often asymptomatic in immunocompetent individuals, the virus can cause severe disease in neonates and immunocompromised patients. CMV is the most common cause of congenital viral infection in the United States, and a major pathogen in solid organ and hematopoietic stem cell transplant recipients.CMV is transmitted via bodily fluids, sexual...
Genital Herpes
Genital herpes is a sexually transmitted infection primarily caused by herpes simplex virus type 2 (HSV-2), though herpes simplex virus type 1 (HSV-1) is increasingly implicated in genital infections, particularly among younger populations. Transmission occurs mainly through sexual contact, with asymptomatic viral shedding serving as a major route of spread. This characteristic makes HSV-2 difficult to control at a population level, as individuals may unknowingly transmit the virus even in the...
