揭示人类疹病毒对中枢神经系统感染的影响:一项观察性研究
Caio Cesar L B Barrionuevo1, Pedro P A Baptista2, Ewerton F da Silva3
1Programa de Pós Graduação em Medicina Tropical, Universidade do Estado do Amazonas, Manaus 69055-038, Brazil.
Viruses
|September 28, 2024
概括
人类疹病毒 (HHV) 与神经系统疾病 (如脑炎) 有关. 这项研究在7.5%的患者中发现了HHV,特别是人类细胞巨乳病毒和爱斯坦-巴尔病毒,特别是在艾滋病毒/艾滋病患者中.
科学领域:
- 神经病毒学 神经病毒学
- 传染性疾病 传染性疾病
- 分子诊断学 分子诊断
背景情况:
- 人类疹病毒 (HHV) 涉及显著的神经疾病,包括脑炎和脑膜炎.
- 中枢神经系统 (中枢神经系统) 感染HHV带来了相当大的临床挑战,特别是在免疫功能低下的人群中.
研究的目的:
- 以回顾分析HHV对出现神经症状的患者的影响.
- 调查赫尔佩斯病毒家族,特别是细胞巨乳病毒在中枢神经系统感染中的作用.
主要方法:
- 这是一项对895名疑似病毒中枢神经系统感染的患者进行的回顾性队列研究.
- 在脑脊液 (CSF) 样本上使用定量聚合酶链反应 (qPCR) 进行分子诊断.
- 来自巴西西部亚马逊地区的第三级护理医院收集的数据 (2015年1月至2022年12月).
主要成果:
- 7.5%的样本检测出HHV阳性,其中人类细胞巨乳病毒 (HCMV) 和爱斯坦-巴尔病毒 (EBV) 是最常见的.
- 观察到HHV与神经系统疾病 (脑炎,脑膜炎) 之间存在显著的关联,特别是在艾滋病毒/艾滋病感染者 (PLWHA) 中.
- 脑液分析对于诊断中枢神经系统感染至关重要,由于免疫性损害,HIV患者的治疗复杂.
结论:
- 对于免疫功能低下个体中中枢神经系统感染,全面的诊断策略和量身定制的治疗方法至关重要.
- 需要进一步的研究和临床进展,以改善HCV相关的中枢神经系统感染患者的治疗结果.
相关概念视频
Herpes
Herpes simplex type 1 (HSV‑1) is a widespread pathogen responsible for orolabial lesions. It is an enveloped, double-stranded DNA (dsDNA) virus belonging to the family Herpesviridae. Once the virus infects a host cell, its double‑stranded DNA genome is delivered into the nucleus, where a coordinated cascade of immediate‑early, early, and late gene expression directs viral DNA replication, structural protein synthesis, and virion assembly. After primary infection of epithelial cells, HSV-1...
Arboviral Encephalitis
Arboviral encephalitis refers to brain inflammation caused by arthropod-borne viruses, particularly those transmitted through mosquito vectors. Among these, West Nile virus (WNV), a member of the Flaviviridae family, is a significant public health concern. WNV is an enveloped, positive-sense, single-stranded RNA virus. Human infection typically begins when an infected mosquito introduces the virus into the dermis during feeding. The primary transmission cycle involves birds as amplifying hosts...
Cytomegalovirus Disease
Cytomegalovirus (CMV) disease is caused by human cytomegalovirus, a double-stranded DNA virus of the Herpesviridae family. While primary CMV infection is often asymptomatic in immunocompetent individuals, the virus can cause severe disease in neonates and immunocompromised patients. CMV is the most common cause of congenital viral infection in the United States, and a major pathogen in solid organ and hematopoietic stem cell transplant recipients.CMV is transmitted via bodily fluids, sexual...
Genital Herpes
Genital herpes is a sexually transmitted infection primarily caused by herpes simplex virus type 2 (HSV-2), though herpes simplex virus type 1 (HSV-1) is increasingly implicated in genital infections, particularly among younger populations. Transmission occurs mainly through sexual contact, with asymptomatic viral shedding serving as a major route of spread. This characteristic makes HSV-2 difficult to control at a population level, as individuals may unknowingly transmit the virus even in the...
Encephalitis l: Introduction
Encephalitis is inflammation of the brain parenchyma, most often due to infections or autoimmune processes. It presents with neuropsychiatric features such as fever, altered mental status, behavioral changes, cognitive dysfunction, seizures, focal deficits, and sometimes autonomic instability. In some cases, the meninges are also involved, resulting in meningoencephalitis.Infectious CausesInfectious encephalitis is most commonly viral but can also result from bacterial, fungal, or parasitic...
Encephalitis ll: Pathophysiology
Encephalitis is inflammation of the brain parenchyma caused by direct viral invasion or immune-mediated mechanisms triggered by infections or tumors. Both processes lead to neuronal injury, disrupted neurotransmission, and diverse neurological symptoms, often with overlapping clinical and pathological features.Autoimmune EncephalitisIn autoimmune encephalitis, antibodies target neuronal antigens on cell surfaces, synapses, or within neurons. A key example is anti-NMDAR encephalitis, which can...


