耐力运动不会在mRNACOVID-19疫苗接种后BALB/c小鼠中加剧心脏炎症
Sander Eens1,2, Manon Van Hecke3, Siel Van den Bogaert2
1Research Group Cardiovascular Diseases, GENCOR, University of Antwerp, 2610 Antwerp, Belgium.
Vaccines
|September 28, 2024
概括
mRNA COVID-19 疫苗似乎对心脏是安全的,即使有运动. 这项研究没有发现任何证据表明,在小鼠接种疫苗后,身体活动会增加心脏炎症.
科学领域:
- 免疫学 免疫学 免疫学
- 心脏病学 心脏病学
- 疫苗学 疫苗学 疫苗学
背景情况:
- 心肌炎是mRNACOVID-19疫苗接种后的罕见不良事件,特别是在年轻男性中.
- 身体炼的潜在机制和潜在影响仍然不清楚.
研究的目的:
- 为了调查与mRNA COVID-19疫苗接种同时进行的体育炼是否会促进心脏炎症.
- 为了评估mRNA COVID-19疫苗的心脏安全性.
主要方法:
- 雄性BALB/c小鼠在跑步机上跑步或静坐5周.
- 小鼠接受了两剂Pfizer/BioNTech疫苗或载体,并继续进行运动.
- 进行了心脏组织分析,体重监测和免疫学测试.
主要成果:
- 接种疫苗引起的体重减轻,肝炎和抗原特异性T细胞反应.
- 在右心室观察到轻微的纤维血管炎症和细胞损失,独立于疫苗接种或运动.
- 疫苗接种后没有检测到心脏类素水平的显著增加.
- 接种疫苗的小鼠显示了心脏IFNγ和IL-1βmRNA的升高调节,但运动并没有使这种情况恶化.
结论:
- 在这种小鼠模型中,mRNA COVID-19 疫苗接种证明了心脏安全性.
- 耐力运动并没有加剧与疫苗相关的炎症性心脏变化.
- 这项研究没有确定运动对与mRNA疫苗相关的心肌瘤发作的作用.
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