在免疫效应细胞疗法后,对疹,风疹和肺炎球菌的幽默免疫和抗体反应:一项前性研究
Georgios Angelidakis1, Roy F Chemaly1, Pranoti V Sahasrabhojane2,3
1Departments of Infectious Diseases, Infection Control and Employee Health, Division of Internal Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
接受免疫效应细胞疗法 (IECT) 的患者通常会失去免疫力. 在IECT后,结和耳的抗体水平仍然很高,但肺炎球菌免疫力下降,需要新的疫苗接种策略.
科学领域:
- 免疫学 免疫学 免疫学
- 传染性疾病 传染性疾病
- 在瘤学瘤学.
背景情况:
- 接受免疫效应细胞疗法 (IECT) 的患者面临感染的重大风险.
- 维持保护性免疫对于这种脆弱的患者群体至关重要.
研究的目的:
- 评估IECT前后对肺炎球菌,结节病和耳病的阳性.
- 为了评估IECT后患者接种疫苗的反应.
主要方法:
- 从2020年1月到2022年3月接受IECT的患者的潜在招生.
- 在基线,IECT后1个月和3-6个月测量喉炎,结节炎和肺炎球菌的抗体水平.
- 在IECT后接种疫苗给了符合条件的患者.
主要成果:
- 在IECT前,对破伤风 (99%) 和喉 (94%) 的血清保护水平高,但对于肺炎球菌 (36%) 的血清保护水平低.
- 在IECT后,对破伤风 (100%) 和喉 (91-100%) 的血清保护水平保持不变.
- 肺炎球菌血清保护在IECT后降低 (79-91%),15名患者对IECT后接种疫苗没有反应.
结论:
- 免疫效应细胞疗法可能导致免疫力丧失,特别是针对肺炎球菌.
- 当前的疫苗接种策略可能在IECT后不足.
- 在IECT之后,对优化疫苗接种方案的进一步研究是有必要的.
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