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Updated: Jun 11, 2025

Residue-Specific Exchange of Proline by Proline Analogs in Fluorescent Proteins: How "Molecular Surgery" of the Backbone Affects Folding and Stability
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Residue-Specific Exchange of Proline by Proline Analogs in Fluorescent Proteins: How "Molecular Surgery" of the Backbone Affects Folding and Stability

Published on: February 3, 2022

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一个整合性表征的proline cis和转变的 conformers 在一个无序的

Alice J Pettitt1, Vaibhav Kumar Shukla2, Angelo Miguel Figueiredo3

  • 1Department of Structural and Molecular Biology, Division of Biosciences, London, United Kingdom; Department of Engineering, Faculty of Natural, Mathematical and Engineering Sciences, King's College London, London, United Kingdom; The Francis Crick Institute, London, United Kingdom.

Biophysical journal
|September 28, 2024
PubMed
概括

使用分子动力学 (MD) 模拟和NMR,研究了内在失序蛋白 (IDP) 动态. 该研究使用增强的采样方法在SARS-CoV-2ORF6 C末端区域 (ORF6CTR) 中表征了proline cis/trans异构.

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