对患有抑郁症和创伤史的患者使用普拉佐辛的增加:一项随机,双盲,安慰剂控制的随机研究
Ping Guo1,2, Yong Xu3, Liang Lv2
1Department of Mental Health, Children's Hospital of Soochow University, Suzhou, Jiangsu, China.
Acta psychiatrica Scandinavica
|September 28, 2024
概括
低剂量普拉佐辛有效改善了创伤病史患者的抑郁和焦虑症状. 与安慰剂相比,这种治疗增强策略显示出显著的症状改善和更高的响应率,可控的副作用包括轻度静止性低血压.
科学领域:
- 精神病学和药理学 精神病学和药理学
- 临床神经科学 临床神经科学
- 创伤信息化的护理
背景情况:
- 经历创伤的抑郁症往往对标准抗抑郁药物反应不佳.
- 普拉佐辛是一种α-1上腺受体阻断剂,对像梦一样的PTSD症状有前途.
- 由于预后不佳,对创伤幸存者抑郁症的普拉佐辛的调查至关重要.
研究的目的:
- 评估低剂量普拉佐辛 (0.5-1毫克/天) 的疗效和耐受性,作为在有创伤病史的患者中治疗抑郁症的补充疗法.
- 评估与安慰剂相比,普拉佐辛是否能快速缓解症状并改善治疗结果.
- 为了确定prazosin增强在这个人群中的安全概况.
主要方法:
- 一个随机,双盲,安慰剂对照试验,涉及59名患有抑郁症和创伤史的患者.
- 参与者接受了标准抗抑郁药加上普拉佐辛 (0.5-1毫克/天) 或安慰剂6周.
- 使用蒙哥马利-阿斯伯格抑郁评分表,HAMD-17和HAMA分数来衡量有效性.
主要成果:
- 普拉佐辛增剂在第3天导致HAMD-17和HAMA得分在统计学上显著改善.
- 在普拉佐辛组的响应率在第4周 (56.7%对24.1%) 和第6周 (80.0%对48.3%) 显著更高.
- 两组之间的不良事件是相似的,尽管普拉佐辛减少了失眠/梦,但增加了轻度至中度的正静性低血压.
结论:
- 低剂量普拉佐辛是一种有效的增强策略,用于改善患有抑郁症和创伤史的患者的情绪症状.
- 观察到的主要不良影响是轻度至中度的静止性低血压.
- 普拉佐辛为这个具有挑战性的患者群体提供了潜在的治疗选择.
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