产前和生命早期的暴露引起的神经毒性
Aluru Parithathvi1, Neha Choudhari2, Herman S Dsouza1
1Department of Radiation Biology and Toxicology, Manipal School of Life Sciences, Manipal Academy of Higher Education, Manipal, India.
Human & experimental toxicology
|September 28, 2024
概括
产前暴露会损害发育中的大脑,影响认知和行为. 对于儿童来说,没有安全的暴露水平,造成神经发育和神经退行性疾病的风险.
科学领域:
- 环境健康 环境健康
- 神经科学是一个神经科学.
- 发育毒理学 发展毒理学
背景情况:
- (Pb) 是一种普遍存在的环境污染物,对公共健康有重大影响.
- 暴露可以通过各种途径发生,导致对人类健康的有毒影响.
- 产前和生命早期阶段特别容易受到的有害影响.
研究的目的:
- 审查毒性对产前和生命早期神经发育的影响.
- 阐明引起的神经毒性的机制,重点关注离子 (Ca2+) 调节.
- 讨论早期暴露的长期后果,包括神经退行性疾病.
主要方法:
- 对暴露和神经发育研究的文献综述.
- 对对神经干细胞和质细胞的影响背后机制的分析.
- 检查流行病学数据,将早期的暴露与晚年神经学结果联系起来.
主要成果:
- 暴露会向胎儿的神经干细胞,损害神经和质细胞的发育.
- 会破坏离子 (Ca2+) 稳态,这是神经发育毒性的关键机制.
- 没有确定儿童暴露的安全值,对认知和行为有记录的影响.
结论:
- 产前和生命早期的暴露对神经发育构成重大风险,影响认知和行为结果.
- 暴露与神经系统疾病的风险增加有关,包括阿尔茨海默氏症和帕金森病在晚年.
- 了解在怀孕,哺乳期和幼儿时期的影响对于减轻长期神经损伤至关重要.
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