基于纳米颗粒的鼻内输送用于治疗不同中枢神经系统疾病的近期进展
Eman A Bseiso1, Nermin M Sheta1, Khaled M Abdel-Haleem1
1Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, October 6 University, Giza Governorate, Giza, Egypt.
Pharmaceutical development and technology
|September 28, 2024
概括
鼻内纳米配方提供了一种有希望的非侵入性方法,可以克服血脑屏障 (BBB),用于治疗中枢神经系统 (CNS) 疾病,如缺血性中风.
科学领域:
- 神经科学是一个神经科学.
- 药理学 药理学是指药理学的学科.
- 生物技术是生物技术.
背景情况:
- 像血脑屏障 (BBB) 这样的生物障碍阻碍了有效的药物输送到中枢神经系统 (CNS).
- 神经退行性疾病和诸如缺血性中风等疾病需要先进的治疗策略来准大脑.
- 非侵入性药物输送方法对于提高治疗疗效和患者服药性至关重要.
研究的目的:
- 审查针对药物输送中枢神经系统的挑战.
- 探索鼻内纳米配方在治疗神经疾病方面的潜力.
- 为了突出纳米载体治疗的进展为大脑准.
主要方法:
- 对用于中枢神经系统药物输送的纳米载体系统的最新研究进行审查.
- 分析鼻腔内注射作为大脑药物运输的直接途径.
- 对脂质和聚合物纳米载体的研究,包括纳米颗粒和小粒.
主要成果:
- 纳米粒子输送系统,如聚合物纳米粒子和基于脂质的纳米载体,在向大脑方面表现出有效性.
- 在中枢神经系统治疗中,鼻内注射增强了BBB的透性和药物的生物可用性.
- 纳米载体有助于防止药物外流,确保在患病部位的最佳治疗度.
结论:
- 内鼻纳米配方代表了中枢神经系统非侵入性药物输送的重大进步.
- 这些新的配方具有很大的潜力来治疗各种神经疾病,包括缺血性中风.
- 对药物载荷纳米载体的进一步研究对于推进中枢神经系统疗法至关重要.
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