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植物雌激素干预和雌激素受体β基因型对前列腺癌扩散和PSA度的影响-随机对照试验
Rebecca Ahlin1,2, Andreas Josefsson3,4,5, Sanna Nybacka6
1Division of Clinical Cancer Epidemiology, Institute of Clinical Sciences, Department of Oncology, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden.
Nutrition and cancer
|September 28, 2024
概括
富含植物雌激素的饮食可能会降低前列腺癌瘤的生长和前列腺特异性抗原 (PSA) 水平. 这种饮食的影响受到雌激素受体-β (ERβ) 基因变异的影响,在接受前列腺切除术的男性中进行了研究.
科学领域:
- 在瘤学瘤学.
- 营养科学 营养科学
- 遗传学 是一个遗传学.
背景情况:
- 植物雌激素,植物衍生化合物具有雌激素类似的特性,正在研究它们在缓解前列腺癌进展中的潜在作用.
- 植物性雌激素的疗效可能由个体遗传变异来调节,特别是雌激素受体β (ERβ) 基因.
研究的目的:
- 研究植物雌激素丰富的饮食对前列腺癌男性瘤增殖和前列腺特异性抗原 (PSA) 水平的影响.
- 为了探索富含植物性雌激素的饮食对前列腺癌标志物的影响是否基于雌激素受体-β (ERβ) 基因多态化而有所不同.
主要方法:
- 一项随机对照试验,涉及140名患有低或中等风险前列腺癌的男性,计划进行激进前列腺切除术.
- 参与者被分配到一个食用大豆和亚麻种子的干预组 (约. 200毫克植物雌激素/天) 持续6周或对照组.
- 评估了瘤增殖 (Ki-67指数),血清PSA水平和ERβ基因多态性.
主要成果:
- 与对照组相比,植物雌激素干预组显示出减少瘤增殖 (较低的Ki-67指数) 的趋势,在TT基因型ERβ载体中观察到的效果最为明显.
- 与对照组相比,干预组中具有TC/CC ERβ基因型的男性表现出PSA度增加的风险明显较低.
- 相反,干预组中TT基因型个体与对照组相比,PSA度增加的风险更高.
结论:
- 富含植物雌激素的饮食可能有助于减少前列腺癌男性的瘤增殖.
- 富含植物雌激素的饮食对PSA水平的影响受到特定雌激素受体-β (ERβ) 基因多态化的影响,这表明个性化的方法可能是有益的.
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