关节可修改风险因素控制和高血压患者中风事件
Xuefei Hou1,2, Suru Yue1,2, Zihan Xu1,2
1Clinical Research Service Center, Affiliated Hospital of Guangdong Medical University, Zhanjiang, China.
Journal of clinical hypertension (Greenwich, Conn.)
|September 28, 2024
概括
管理多种中风风险因素,如血压和胆固醇,可显著降低高血压患者中风风险. 最佳控制,特别是用药物治疗,几乎可以消除高血压.
科学领域:
- 心血管医学 心血管医学
- 神经学 神经学
- 公共卫生 公共卫生
背景情况:
- 高血压是中风的主要危险因素.
- 同时管理可修改的风险因素 (血压,BMI,LDL-C,HbA1c,吸烟,体力活动) 对高血压患者中风的影响尚不清楚.
- 指导方针强调这些因素对中风风险.
研究的目的:
- 调查关节可修改风险因子控制与高血压患者中风风险之间的关联.
- 为了确定多种风险因素的最佳控制是否能减轻高血压相关的中风风险.
主要方法:
- 利用了来自238,388名参与者的英国生物库数据.
- 采用考克斯的比例危险模型来分析中风风险.
- 计算的危险比率 (HR) 和95%的置信区间 (CI).
主要成果:
- 增加对风险因素的控制与降低中风风险相关.
- 高血压患者的最佳控制 (≥5因子) 与较差的控制 (≤2因子) 相比,显示中风风险降低了14.6%.
- 即使在最佳控制下,高血压患者的中风风险比非高血压患者高25.1%.
结论:
- 联合风险因素管理显著降低高血压患者中风风险.
- 结合药理治疗和最佳风险因素控制,可以消除与高血压相关的过度中风风险.
- 药物治疗高血压患者的保护作用更为明显.
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