在银上的乙二联体的协调组合 (I) 盐:晶体结构,抗菌和细胞毒性活动
Quentin Gaudillat1, Jan-Lukas Kirchhoff2, Isabelle Jourdain1
1Université de Franche-Comté, UMR CNRS 6213, Institut UTINAM, 16 Route de Gray, F-25000 Besançon, France.
Inorganic chemistry
|September 28, 2024
概括
基于银的协调聚合物 (CPs) 对黄金葡萄球菌和大肠杆菌具有强大的抗菌活性. 三种合成的CP证明了与人体皮肤纤维细胞的生物相容性,突出了它们作为安全抗菌剂的潜力.
科学领域:
- 材料科学 材料科学 材料科学
- 纳米技术纳米技术
- 药用化学 医学化学
背景情况:
- 协调聚合物 (CP) 和金属有机框架 (MOF) 正成为新型抗菌材料.
- 基于银的化合物尤其以其固有的抗菌特性而闻名.
- 连接体和金属离子选择允许调整CP/MOF拓,维度和建筑单元.
研究的目的:
- 为了探索乙二乙联体与银盐的协调作用.
- 综合和描述基于银的新型CP.
- 评估合成CP的抗菌活性和细胞毒性.
主要方法:
- 合成基于银的协调聚合物,使用,环基和三基替代的乙烯基二乙烯联体.
- 结晶学表征以确定CP的结构和维度.
- 针对金黄色葡萄球菌和大肠杆菌的抗菌分析.
- 对正常人皮肤纤维细胞的细胞毒性评估.
主要成果:
- 形成一个分子宏循环和六个CP具有不同的维度 (1D到2D).
- 大多数CP具有四个协调的银原子在四面体几何学.
- 所有合成的CP都显示出显著的抗菌活性,最小的抑制度在5至40μg的Ag/mL之间.
- 抗菌功效与CP架构,形态或银离子释放无关.
- 三种合成的CP与人类皮肤纤维细胞具有良好的生物相容性.
结论:
- 基于银的新型CP已成功合成和表征.
- 这些CP显示出广泛的抗菌活性,对抗阳性和阴性细菌.
- 选定CP的生物相容性表明它们有治疗应用的潜力.
- 由于结构和活性之间没有相关性,因此需要进一步研究抗菌作用机制.
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