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污水中抗生素耐药性的公共卫生影响:流行病学视角

Kashif Rahim¹, Muhammad Naveed Nawaz², Mazen Almehmadi³

¹College of Life Science and Technology, Beijing University of Chemical Technology, Beijing, 100029, China.

Bioresources and bioprocessing

|September 28, 2024

概括

抗生素耐药性是由于过度使用抗生素而造成的全球健康威胁. 这项研究发现废水中存在高水平的抗生素耐药细菌和基因,强调需要更好的处理和监测.

科学领域:

环境科学环境科学
微生物学微生物学
公共卫生公共卫生

背景情况:

抗生素耐药性 (AR) 是一个重要的全球健康问题.
滥用和过度使用抗生素会导致耐药细菌的出现.
废水作为抗生素耐药性基因 (ARG) 的潜在储存和导体.

研究的目的:

调查城市废水中抗生素耐药细菌 (ARB) 和ARG的流行情况.
为了确定Sutlej河废水中存在的特定细菌物种和耐药基因.
强调废水处理和监测对抗AR的重要性.

主要方法:

一项涉及收集36个废水和接收水样的横截面研究.
细菌分离和鉴定,专注于常见的病原体,如大肠杆菌,肺炎菌, Pseudomonas aeruginosa 和沙门氏菌 spp.
分子分析包括DNA隔离,PCR放大和序列分析以检测特定的ARG.

主要成果:

在城市废水样本中检测到高水平的ARB.
关键病原体的高患病率:大肠杆菌 (90%),肺炎菌 (58%),空气真菌 (55%) 和沙门氏菌. (53%) 的比例.
检测有意义的ARG,包括阿米诺糖化物 (41%),硫胺基 (35%),四环素 (29%),素 (12%). 已注意到对西普罗夫洛克萨,Co-trimoxazole,安皮西林和环素的耐药性.

结论:

城市废水含有各种ARB和ARG,对环境和公共健康构成风险.
需要加强废水处理战略和强有力的监测计划.
关于抗生素使用的更严格的规定和改进的废水管理对于缓解抗生素耐药性的传播至关重要.

关键词:

抗生素耐药性抗生素耐药性全球卫生健康全球卫生健康污水是污水,污水就是污水.

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