评估rimegepant使用模式和新用户中的患者特征:一项基于美国行政索赔的研究
Jessica Ailani1, Motomori Lewis2, Feng Dai2
1Department of Neurology, Medstar Georgetown University Hospital, Washington, DC, USA.
Current medical research and opinion
|September 28, 2024
概括
这项研究揭示了偏头痛患者的rimegepant使用模式. 新用户在急性和预防性治疗中表现出明显的药片使用情况,并指出了先前存在的显著风险因素.
科学领域:
- 神经学 神经学
- 药理学 药理学是指药理学的学科.
- 医疗保健服务研究 医疗服务研究
背景情况:
- 里梅格潘特是一种关键的口服素基因相关抗体,用于急性和预防性偏头痛治疗.
- 它是美国仅有的口服CGRP抗剂,在两种适应症中均已获得批准.
研究的目的:
- 评估新使用rimegepant的药片使用模式.
- 描述开始治疗rimegepant的患者的治疗前特征.
主要方法:
- 使用两个美国商业索赔数据库 (MarketScan和Optum) 的回顾性队列研究.
- 包括患有偏头痛开始的患者 (≥18岁).
- 分为急性 (8片) 和预防性 (15-16片) 的分层.
- 评估了基线特征和药物史的预指数.
- 计算的rimegepant使用量 (每30天一片) 和定义的使用周期.
主要成果:
- 在MarketScan中发现了14,037名rimeegepant使用者,79.8%的急性,13.4%的预防.
- 急性使用:4.9片/30天;预防性使用:13.1片/30天.
- 在rimegepant.使用之前,高患病率的triptan禁忌/警告 (46.2%) 和急性药物过量使用 (25.1%).
- 在Optum数据库中观察到的一致发现.
结论:
- 提供了第一个关于rimegepant药片使用的真实世界数据.
- 描述了rimegepant用于急性和预防性偏头痛管理的新用户.
- 突出显示了这种CGRP对手的患者个人资料和使用模式.
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